Takahiro Shimoyama ¹, Takayuki Yamamoto ², Satoru Umegae ¹, Koichi Matsumoto ¹ , BMC Gastroenterol. 2018 Aug 1;18(1):120.

Our findings indicate that FC is a relevant biomarker, which is convenient to measure for assessing endoscopic activity and predicting relapse in patients who achieve remission following a course of GMA therapy.

https://pubmed.ncbi.nlm.nih.gov/30068300/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090982/pdf/12876_2018_Article_853.pdf

Shoichi Nishise ¹, Yuji Takeda ², Hidetoshi Nara ², Yasuhiko Abe ¹, Yu Sasaki ¹, Hironobu Asao ², Yoshiyuki Ueno ¹ , Ther Apher Dial. 2018 Jun;22(3):261-265.

These results suggest that independent of incubation temperature, sICAM-1 and sVCAM-1 are likely to adsorb CA beads. These molecules may be a new index for predicting the therapeutic effects of GMA.

https://pubmed.ncbi.nlm.nih.gov/29745046/

Helena Rolandsdotter ^1 2, Michael Eberhardson ^1 3, Ulrika L Fagerberg ^4 5, Yigael Finkel ^1 2 , J Pediatr Gastroenterol Nutr 2018 Jan;66(1):84-89.

Objective: The aim of the study was to analyze the effect of granulocyte and monocyte apheresis (GMA) with mesalazine for induction of remission in pediatric patients with newly onset chronic inflammatory bowel disease (IBD) colitis. Methods: Thirteen pediatric patients with newly onset extensive IBD colitis were investigated per the ECCO/ESPGHAN IBD protocol. Of these 13, 12 received 10 treatments with Adacolumn (ADA) during a median of 6.25 weeks in combination with low-to-moderate doses of mesalazine, which was continued after apheresis. A control colonoscopy was performed 12 to 16 weeks after GMA treatment. Primary outcomes were mucosal healing (Mayo endoscopic score) and histopathologic grading of biopsies. A secondary outcome was disease activity as measured by the Pediatric Ulcerative Colitis Activity Index. Results: Twelve children (6 girls) with a median age of 14.6 years and a median duration of symptoms at diagnosis of 3.2 months received all planned 10 treatment sessions with ADA. Ten of 12 patients had pancolitis and 2 of 12 extensive colitis. A final diagnosis, however, indicated ulcerative colitis in 10 children and Crohn disease in 2 children. At control colonoscopy, 8 of 12 children were in clinical remission and the Mayo endoscopic score showed significant improvement in 9 of 12 patients (P = 0.006). Complete microscopic remission, according to the Geboes score, was observed in 2 patients. Conclusions: In this small study GMA for induction of remission of newly onset pediatric IBD colitis was effective in 8 of 12 patients. Further controlled studies are warranted to confirm the efficacy of this treatment model.

https://pubmed.ncbi.nlm.nih.gov/28604509/

Helena Rolandsdotter ^1 2, Kerstin Jönsson-Videsäter ^3 4, Ulrika L Fagerberg ^5 6, Michael Eberhardson ^1 7, Yigael Finkel ^1 2 , J Pediatr Gastroenterol Nutr. 2018 Apr;66(4):e103-e107.

We speculate that the decreases in colonic mucosal cytokine profiles after treatment may explain the observed clinical efficacy in the GMA-treated children with IBD.

https://pubmed.ncbi.nlm.nih.gov/28891831/

Belén Beltrán ^1 2 3, Esteban Sáez-González ¹, Inés Moret ^1 2 3, Francia C Díaz-Jaime ¹, Diego Alvarez-Sotomayor ¹, Elena Cerrillo ^1 2, Marisa Iborra ^1 2 3, Guillermo Bastida ^1 2 3, Mariam Aguas ^1 2 3, Pilar Nos ^1 2 3 , J Clin Apher. 2018 Feb;33(1):99-103

We hypothesize that GMA can help to lower the inflammatory load, thereby enhancing the effect of biologic drugs. 

https://pubmed.ncbi.nlm.nih.gov/28485025/

Asami Fujii ¹, Hidenori Ohnishi ², Mariko Seishima ¹ , Ther Apher Dial. 2018 Feb;22(1):92-93.

https://pubmed.ncbi.nlm.nih.gov/28913961/

Shingo Kato, Akira Ishibashi, Kaori Sugiura, Kazuhito Kani, Tomonari Ogawa, Hajime Hasegawa, Koji Yakabi, Contrib Nephrol 2018;196:200-208.

GMA decreases inflammatory cytokines and upregulates regulatory T cells. Intensive GMA is significantly more effective than weekly GMA in patients with IBD. The frequency of GMA sessions per week positively correlates with treatment effects. GMA can be safely used in pregnant women and children because of its low adverse event rates. Maintenance therapy and rescue therapy for loss of response of anti-tumor necrosis factor (TNF)-α antibodies are effective. Optimal patients who responded to combination therapy with infliximab and GMA showed aggravation characteristics against infliximab treatment at week 4. Key Message: Prospective randomized blinded studies using a sham column should be performed for the loss of response against anti-TNF-α antibodies.

https://pubmed.ncbi.nlm.nih.gov/30041228/

Jia Huang, Qian Wang, Yongjing Cheng, Yingjuan Chen, Ming Gao, Feng Yang, Bingyao Mu, Rongwei Zhou, Cibo Huang, Altern Ther Health Med. 2020 Jul;26(4):36-42.

This study indicated that LCAP therapy can significantly decrease RA disease activity and is a safe and effective alternative therapy. LCAP therapy significantly reduced serum CXCL16 and serotonin levels, offering a putative mechanism by which it improves the articular symptoms of RA.

https://www.worldscientific.com/doi/10.1142/9789814749084_0031

• Helena Rolandsdotter Published 2017 Medicine

Finally, we studied the immunological profile in blood at onset and in intestinal mucosa at onset and after GMA and EEN treatment. We conclude that an active approach is needed in the care of children with IBD to achieve and maintain remission. Our findings reveal that the children on IFX maintenance treatment were only in remission in 28% of the visits. The combination of GMA and mesalazine was found to be a safe and effective treatment in children with newly onset IBD. It seems plausible to speculate that the decreases in mucosal cytokines after the induction of remission may explain the good clinical result. Moreover, a change in the mucosal cytokine profile after induction of remission with EEN was observed. By investigating the chemokine receptors, we found a possible prognostic IBD marker, and by analyzing the cytokine profiles in mucosal biopsies, we have extended the knowledge of immunological phenotypes in children with IBD. Suggestions for the future Corticosteroid-free treatment alternatives must be explored and those currently in use must be optimized. To conclude, more and bigger studies are needed to explore the pathogenesis of IBD to determine new treatment alternatives.

https://www.semanticscholar.org/paper/Pediatric-inflammatory-bowel-disease-%3A-clinical-and-Rolandsdotter/e3d901c2c80db622f6cfbf92b03ee403b6e4a9b6#paper-header

Rolf Bambauer ¹, Reinhard Latza ², Daniel Burgard ³, Ralf Schiel ⁴ ,

Ther Apher Dial 2017 Feb;21(1):6-21.

Here, the authors provide an overview of the most important pathogenic aspects indicating that TA can be a supportive therapy in systemic autoimmune diseases such as renal and neurological disorders. For the immunological diseases that can be treated with TA, the guidelines of the German Working Group of Clinical Nephrology and of the Apheresis Committee of the American Society for Apheresis are cited.

https://pubmed.ncbi.nlm.nih.gov/28078733/