Scientific corner

Physiological heating augments the anti-inflammatory reactions during granulocyte/monocyte apheresis: A in vitro study

Shoichi Nishise 1 2Yuji Takeda 3Yasuhiko Abe 1Yu Sasaki 1Shinichi Saitoh 3Hidetoshi Nara 3Hironobu Asao 3Yoshiyuki Ueno, Ther Apher Dial 2020 Oct 17.

These results indicated that physiological heating of the apheresis carrier augmented the anti-inflammatory reaction in vitro. Thus, heating during GMA may be a new approach for augmenting clinical efficacy.

Scientific corner

JO2-01 Effect of cellulose acetate beads on the release of interleukin-13 at different temperatures

poster at ISFA 2019 pag 146

We investigated the effect of cellulose acetate (CA) beads, carriers for granulocyte and monocyte
adsorptive apheresis (GMA), on the release of interleukin (IL)-13, an inflammatory cytokine. We
incubated peripheral blood with and without CA beads at 5ºc, 25 ºc , 37 ºc and 43 ºc and measured
the IL-13 concentration. The IL-13 concentration in the samples incubated without CA beads
increased as the temperature increased; however, the IL-13 concentration in the samples incubated
with CA beads decreased as the temperature increased from 5 ºc to 37 ºc . These results suggest that
the optimal temperature of GMA for anti-inflammatory effects may be at body temperature.

Scientific corner

Effect of Temperature on Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads.

Shoichi Nishise 1Yuji Takeda 2Yasuhiko Abe 1Yu Sasaki 1Hidetoshi Nara 2Hironobu Asao 2Yoshiyuki Ueno 1 , Ther Apher Dial. 2017 Jun;21(3):248-254.

These results suggest that warming the column during GMA might increase GM adsorption to CA beads, thereby enhancing the clinical efficacy of GMA.

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