Shoichi Nishise ^1 2, Yuji Takeda ³, Yasuhiko Abe ¹, Yu Sasaki ¹, Shinichi Saitoh ³, Hidetoshi Nara ³, Hironobu Asao ³, Yoshiyuki Ueno, Ther Apher Dial 2020 Oct 17.

These results indicated that physiological heating of the apheresis carrier augmented the anti-inflammatory reaction in vitro. Thus, heating during GMA may be a new approach for augmenting clinical efficacy.

https://pubmed.ncbi.nlm.nih.gov/33067913/

poster at ISFA 2019 pag 146

We investigated the effect of cellulose acetate (CA) beads, carriers for granulocyte and monocyte
adsorptive apheresis (GMA), on the release of interleukin (IL)-13, an inflammatory cytokine. We
incubated peripheral blood with and without CA beads at 5ºc, 25 ºc , 37 ºc and 43 ºc and measured
the IL-13 concentration. The IL-13 concentration in the samples incubated without CA beads
increased as the temperature increased; however, the IL-13 concentration in the samples incubated
with CA beads decreased as the temperature increased from 5 ºc to 37 ºc . These results suggest that
the optimal temperature of GMA for anti-inflammatory effects may be at body temperature.

http://www.atalacia.com/isfa/data/abstract.pdf

Shoichi Nishise ¹, Yuji Takeda ², Yasuhiko Abe ¹, Yu Sasaki ¹, Hidetoshi Nara ², Hironobu Asao ², Yoshiyuki Ueno ¹ , Ther Apher Dial. 2017 Jun;21(3):248-254.

These results suggest that warming the column during GMA might increase GM adsorption to CA beads, thereby enhancing the clinical efficacy of GMA.

https://pubmed.ncbi.nlm.nih.gov/28661094/