Scientific corner

JO2-01 Effect of cellulose acetate beads on the release of interleukin-13 at different temperatures

poster at ISFA 2019 pag 146

We investigated the effect of cellulose acetate (CA) beads, carriers for granulocyte and monocyte
adsorptive apheresis (GMA), on the release of interleukin (IL)-13, an inflammatory cytokine. We
incubated peripheral blood with and without CA beads at 5ºc, 25 ºc , 37 ºc and 43 ºc and measured
the IL-13 concentration. The IL-13 concentration in the samples incubated without CA beads
increased as the temperature increased; however, the IL-13 concentration in the samples incubated
with CA beads decreased as the temperature increased from 5 ºc to 37 ºc . These results suggest that
the optimal temperature of GMA for anti-inflammatory effects may be at body temperature.

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