poster at ISFA 2019 pag 146

We investigated the effect of cellulose acetate (CA) beads, carriers for granulocyte and monocyte
adsorptive apheresis (GMA), on the release of interleukin (IL)-13, an inflammatory cytokine. We
incubated peripheral blood with and without CA beads at 5ºc, 25 ºc , 37 ºc and 43 ºc and measured
the IL-13 concentration. The IL-13 concentration in the samples incubated without CA beads
increased as the temperature increased; however, the IL-13 concentration in the samples incubated
with CA beads decreased as the temperature increased from 5 ºc to 37 ºc . These results suggest that
the optimal temperature of GMA for anti-inflammatory effects may be at body temperature.

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