Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases

Maria K. Skytthe,¹ Jonas Heilskov Graversen,^1,* and Søren K. Moestrup, Int J Mol Sci. 2020 Aug; 21(15): 5497.

In conclusion, the specific targeting of CD163⁺ macrophages has been demonstrated to be a promising drug delivery strategy for handling inflammatory and malignant disease, contributing to the current pharmaceutical therapies.

(nih.gov)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432735/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432735/pdf/ijms-21-05497.pdf

cancer / CD163 / Glucocorticoid / immunology /

Scientific corner

2017

Sequential therapy consisting of glucocorticoid infusions followed by granulocyte-monocyte absorptive apheresis in patients with severe alcoholic hepatitis.

Kazuhiro Watanabe¹, Yoshihito Uchida¹, Kayoko Sugawara¹, Kayoko Naiki¹, Mie Inao¹, Nobuaki Nakayama¹, Satoshi Mochida² , J Gastroenterol 2017 Jul;52(7):830-837.

Sequential therapy combining glucocorticoid infusion and GMA was useful for attenuating liver injuries in patients with severe alcoholic hepatitis by preventing rebound increases in inflammatory reactions after discontinuation of glucocorticoid infusions, except in patients with bacterial infections and/or multiple organ failure.

https://pubmed.ncbi.nlm.nih.gov/27858246/

Alcoholic hepatitis / combination / cytokines / digestive / Glucocorticoid / immunology /

Contact UsFor more information