Scientific corner

A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn’s disease.

Bruce E Sands 1Seymour KatzDouglas C WolfBrian G FeaganTao WangLisa-Marie GustofsonCindy WongMargaret K VandervoortStephen Hanauer, Gut. 2013 Sep;62(9):1288-94.

GMA was well tolerated, but this study did not demonstrate its effectiveness over a sham procedure in inducing clinical remission or response in patients with moderate to severe CD.

Scientific corner

Adsorptive granulocyte/monocyte apheresis for the maintenance of remission in patients with ulcerative colitis: a prospective randomized, double blind, sham-controlled clinical trial.

Ken Fukunaga 1Yoko YokoyamaKoji KamokozuruKazuko NagaseShiro NakamuraHiroto MiwaTakayuki Matsumoto, Gut Liver. 2012 Oct;6(4):427-33.

Monthly GMA may potentially prevent UC relapse in patients who have achieved remission through weekly GMA, especially in patients on <20 mg/day PSL at the start of the maintenance therapy.

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