Scientific corner

A positive clinical experience of a long-term treatment pattern with leukocyte apheresis and Adacolumn in ulcerative proctitis.

Elena Borrego García 1María Peña Ortega 2Alicia Martín-Lagos Maldonado 3 , Rev Esp Enferm Dig. 2019 Nov;111(11):889.

Ulcerative proctitis (UP) is often involved in the diagnosis of inflammatory bowel disease (IBD). The increase of leukocytes and pro-inflammatory factors in peripheral blood and in the active forms, as well as the infiltration of neutrophils and monocytes/macrophages in the intestinal mucosa is known to occur in this entity. This infiltration of cells damages the mucosa due to the liberation of proteases, oxidation radicals and cytokines, among others. Apheresis techniques such as leukocyte apheresis may be used among the different therapeutic options such as steroids, sulfasalazine, 5-aminosalicylic, tacrolimus, azathioprine, cyclosporine, mycophenolate and biological agents.

Scientific corner

Cytapheresis in patients with severe ulcerative colitis after failure of intravenous corticosteroid: a long-term retrospective cohort study

Ken Fukunaga 1Kazuko NagaseTakeshi KusakaNobuyuki HidaYoshio OhdaKoji YoshidaKatsuyuki TozawaKoji KamikozuruM IimuroShiro NakamuraHiroto MiwaTakayuki Matsumoto, Gut Liver. 2009 Mar;3(1):41-7. doi: 10.5009/gnl.2009.3.1.41

This study suggest that CAP is an effective therapy in patients who are refractory to conventional medications including iv corticosteroid. Increased remission rates should be expected in refractory patients with moderately severe UC.

Scientific corner

Down-regulation of interfeferon-γ parallels clinical response to selective leukocyte apheresis in patients with inflammatory bowel disease:a 12-month follow-up study

V Muratov 1J LundahlA K UlfgrenK ElvinI FehrmanN AhlborgA OstN HittelA SaniabadiR Löfberg, Int J Colorectal Dis . 2006 Sep;21(6):493-504.

Leukocyte apheresis is a novel and safe nonpharmacological adjunct therapy that may prove useful in steroid refractory or dependent patients when conventional drugs have failed. Down-regulation of IFN-gamma in mucosal biopsies and in peripheral leukocytes may be a predictive marker for sustained, long-term response.

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