Scientific corner

Adsorptive Granulocyte and Monocyte Apheresis Is Effective in Ulcerative Colitis Patients Both with and without Concomitant Prednisolone

Keiji Matsuda 1 2Kohei Ohno 1Yuka Okada 1Takahiro Yagi 1Mitsuo Tsukamoto 1Yoshihisa Fukushima 1Atsushi Horiuchi 1Ryu Shimada 1 2Tsuyoshi Ozawa 1 2Tamuro Hayama 1 2Takeshi Tsuchiya 1 2Junko Tamura 1Hisae Iinuma 1Keijiro Nozawa 1 2Hitoshi Aoyagi 2 3Akari Isono 2 3Koichiro Abe 2 3Shinya Kodashima 2 3Takatsugu Yamamoto 2 3Yoshitaka Kawasaki 4Yoshifuru Tamura 4Yuko Sasajima 5Fukuo Kondo 5Yojiro Hashiguchi 1 2 , Inflamm Intest Dis, 2020 Feb;5(1):36-41.

The effect of GMA with concomitant PSL (Prednisolone) and that of GMA without PSL were not different, and GMA was effective irrespective of PSL administration. The present study showed that GMA had efficacy and led many UC patients treated by PSL to be steroid free with no safety concern in the real world, although there is the possibility of recruitment bias due to the retrospective nature of the study.

https://pubmed.ncbi.nlm.nih.gov/32232053/

https://www.karger.com/Article/Pdf/505484

Scientific corner

Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders.

Rodolfo Sacco 1Tomotaka TanakaTakayuki YamamotoGiampaolo BresciAbbi R Saniabadi, Expert Rev Gastroenterol Hepatol. 2015 Mar;9(3):327-33.

The authors’ view is that in patients with UC, there is an evolving scope for therapeutic opportunity based on taking away the sources of inflammatory cytokines, also considering the favorable safety profile of GMA.

https://pubmed.ncbi.nlm.nih.gov/25160857/

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