Scientific corner

Effect of intensive granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis positive for cytomegalovirus.

Takumi Fukuchi 1Hiroshi NakaseMinoru MatsuuraTakuya YoshinoTakahiko ToyonagaKatsuyuki OhmoriSatoshi UbukataAya UedaTakaaki EguchiHiroshi YamashitaDai ItoKiyoshi Ashida, J Crohns Colitis. 2013 Nov;7(10):803-11.

Intestinal inflammation might trigger CMV reactivation in a subpopulation of active UC patients without CS treatment. GMAA could be a promising option for active UC positive for CMV.

https://pubmed.ncbi.nlm.nih.gov/23352104/

https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/179280

Scientific corner

Effect and Safety of Granulocyte-Monocyte Adsorption Apheresis for Patients with Ulcerative Colitis Positive for Cytomegalovirus in Comparison with Immunosuppressants.

Takuya Yoshino 1Hiroshi NakaseMinoru MatsuuraKayoko MatsumuraYusuke HonzawaTakumi FukuchiKenji WatanabeMitsuyuki MuranoTomoyuki TsujikawaKen FukunagaTakayuki MatsumotoTsutomu Chiba, Digestion. 2011;84(1):3-9.

The colectomy ratio tends to be high in refractory UC patients with recurrent CMV reactivation or infection. Therefore, GMA might be a safe and effective treatment for UC patients positive for CMV because it does not induce CMV reactivation.

https://pubmed.ncbi.nlm.nih.gov/21311190/

https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/183987

Scientific corner

Potential role of granulocyte/monocyte adsorptive apheresis for ulcerative colitis with concomitant CMV infection: authors’ reply

H. NakaseM. MatsuuraT. Chibam , https://doi.org/10.1111/j.1365-2036.2010.04552.x

These new data suggest that GMAA might be safe and effective for UC patients positive for CMV because it does not cause CMV reactivation. Because CMV reactivation might affect the clinical outcome of patients with refractory UC,5 GMAA could be a promising option for UC patients with CMV infection. A new clinical trial with a larger number of patients is ongoing to evaluate further the effects of GMA on UC patients with CMV infection.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2036.2010.04552.x

Scientific corner

Potential role of granulocyte/monocyte adsorptive apheresis for ulcerative colitis with concomitant CMV infection

H. Nakase, M. Matsuura& T. Chiba, doi:10.1111/j.1365-2036.2010.04552.x

These new data suggest that GMAA might be safe and effective for UC patients positive for CMV because it does not cause MV reactivation. Because CMV reactivation might affect the clinical outcome of patients with refractory UC,5 GMAA could be a promising option for UC patients with CMV infection. A new clinical trial with a larger number of patients is ongoing to evaluate further the effects of GMA on UC patients with CMV infection

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2036.2010.04552.x

Contact UsFor more information

Contact Us