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HLA-DR(hi) and CCR9 Define a Pro-Inflammatory Monocyte Subset in IBD.

Ludvig Linton 1Mats KarlssonJeanette GrundströmEric HjalmarssonAnnelie LindbergEmma LindhHans GliseRagnar BefritsIzabella JanczewskaPer KarlénOla WinqvistMichael Eberhardson, Clin Transl Gastroenterol. 2012 Dec 20;3(12):e29.

CD14(+)HLA-DR(hi) blood monocytes were increased in patients with active IBD. These monocytes exhibit a pro-inflammatory, gut-homing phenotype with regard to their TNF-α production and expression of CCR9. Our results suggest that these monocytes are important in mediating intestinal inflammation, and provide potential therapeutic targets in IBD.

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