Scientific corner

Therapeutic Apheresis in Pregnancy: Three Differential Indications With Positive Maternal and Fetal Outcome

Giuseppina Perrone 1Roberto Brunelli 1Eleonora Marcoccia 1Ilaria Zannini 1Miriam Candelieri 1Maria Gozzer 2Claudia Stefanutti 3

When approaching TA in pregnancy, clinicians have to consider the severity of disease, the strength of the indications, and the gestational age. Each case must be evaluated individually on the basis of existing evidence since, despite the increasing use, specific guidelines for apheresis in pregnancy are still lacking.

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The selective therapeutic apheresis procedures

The selective therapeutic apheresis procedures.

J. Clin. Apheresis 28:20–29, 2013  doi:10.1002/jca.21265 

Selective apheresis procedures have been developed to target specific molecules, antibodies, or cellular elements
in a variety of diseases. The advantage of the selective apheresis procedures over conventional therapeutic plasmapheresis is preservation of other essential plasma components such as albumin, immunoglobulins, and clotting
factors. These procedures are more commonly employed in Europe and Japan, and few are available in the
USA. Apheresis procedures discussed in this review include the various technologies available for low-density
lipoprotein (LDL) apheresis, double filtration plasmapheresis (DFPP), cryofiltration, immunoadsorption procedures, adsorption resins that process plasma, extracorporeal photopheresis, and leukocyte apheresis.

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