Scientific corner

Dose-intensified granulocyte-monocyte apheresis in therapy refractory ulcerative colitis

Caroline Schultheiß 1René WeischenbergAndrea HerrmannBernhard HallerRoland M SchmidWolfgang ReindlWolfgang Huber, Artif Organs . 2015 Feb;39(2):187-92

Dose-intensified GMA as reported in this study provided an encouraging short-term response rate of 70% in patients with moderately to severely active UC not responding to standard steroid or immunomodulator therapy. Although all patients relapsed not later than 16 weeks, GMA might be useful to reduce steroid and immunomodulator usage, or to delay surgery in this patient group.


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