Scientific corner

Down-regulation of interfeferon-γ parallels clinical response to selective leukocyte apheresis in patients with inflammatory bowel disease:a 12-month follow-up study

V Muratov 1J LundahlA K UlfgrenK ElvinI FehrmanN AhlborgA OstN HittelA SaniabadiR Löfberg, Int J Colorectal Dis . 2006 Sep;21(6):493-504.

Leukocyte apheresis is a novel and safe nonpharmacological adjunct therapy that may prove useful in steroid refractory or dependent patients when conventional drugs have failed. Down-regulation of IFN-gamma in mucosal biopsies and in peripheral leukocytes may be a predictive marker for sustained, long-term response.

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