Yuko Higashi ^1 2, Atsuko Ibusuki ¹, Tomoko Fukushige ¹, Ryoko Sagara ¹, Risako Yonezawa ¹, Natsumi Terada ¹, Hisao Kawahira ¹, Kimiko Kazumura ³, Takuro Kanekura ¹

Ther Apher Dial. 2025 Aug;29(4):702-706. doi: 10.1111/1744-9987.70043. Epub 2025 May 25.

Introduction: Activated neutrophils play a crucial role in the development of neutrophilic dermatoses, including pustular psoriasis. Adsorptive granulocyte and monocyte apheresis (GMA) is an effective treatment for skin disorders. Although previous basic research has demonstrated neutrophil activation, no efficient method exists to assess it in clinical settings.

Methods: We measured neutrophil activity in patients with GPP who underwent GMA therapy using the FLP-H4200, a newly developed neutrophil activity evaluation system. Blood samples were collected before the first and after the fifth GMA session.

Results: In Case 1, which responded to GMA, the neutrophil activation value decreased from 118 603 to 26 234, reaching the normal range. In Case 2, the response to GMA was poor, and the neutrophil activation value decreased from 140 623 to 76 780, which remained significantly above the normal level.

Conclusion: These results suggest that the neutrophil activity evaluation system may be useful for assessing disease severity and therapeutic efficacy.