Scientific corner

Daily granulocyte and monocyte adsorptive apheresis in patients with active ulcerative colitis: a prospective safety and feasibility study

Takayuki Yamamoto 1Satoru UmegaeKoichi Matsumoto, J Gastroenterol 2011 Aug;46(8):1003-9.

This is the first report on daily GMA in the treatment of patients with UC. Daily GMA was safe and well tolerated without serious AE. Furthermore, daily GMA was associated with rapid improvement of clinical symptoms in patients with moderately active UC. However, controlled trials are warranted to assess a definite efficacy for daily GMA therapy.

Scientific corner

Pilot Feasibility Studies of Leukocytapheresis With the Adacolumn Apheresis System in Patients With Active Ulcerative Colitis or Crohn Disease

Bruce E Sands 1William J SandbornDouglas C WolfSeymour KatzMichael SafdiDavid A SchwartzStephen B Hanauer, J Clin Gastroenterol. 2006 Jul;40(6):482-9.

Treatment with Adacolumn may be feasible and effective in patients with moderate-to-severe refractory inflammatory bowel disease. Larger sham-controlled studies are ongoing.

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