Scientific corner

Adsorptive depletion of α4 integrin(hi)- and CX3CR1(hi)-expressing proinflammatory monocytes in patients with ulcerative colitis

Shin-ichiro Takeda 1Toru SatoTatsuro KatsunoTomoo NakagawaYoshiko NoguchiOsamu YokosukaYasushi Saito, Dig Dis Sci. 2010 Jul;55(7):1886-95.

We found high expressions of alpha4 integrin and CX(3)CR1 on monocytes in patients with active UC, known to promote the extravasation of CD14(+)CD16(+) monocytes into the mucosa. GMA effectively depletes CD14(+)CD16(+) monocytes and concomitantly increases CD14(hi)CD16(-)CCR2(low) “immature” monocytes; thus GMA was associated with the emergence of less inflammatory monocyte phenotype in circulation.

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