Successful treatment of pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome with granulocyte and monocyte adsorption apheresis

Miho Hatanaka ¹, Kazuyasu Fujii ¹, Takuro Kanekura ¹ J Dermatol 2021 Aug;48(8):e376-e377. doi: 10.1111/1346-8138.15946. 

Pyoderma gangrenosum (PG), acne(A), and Suppurative hidradenitis (SH) syndrome (PASHs) is a recently proposed disease entity clinically characterized by PG, acne, and SH, belonging to the spectrum of hereditary autoinflammatory syndrome with PG. Although biologic agents targeting interleukin-1 and tumor necrosis factor-α have been recommended for the treatment of PASHs, their efficacy has not been well established because of its rarity.
Granulocyte and monocyte adsorption apheresis is an extracorporeal apheresis unit designed to selectively remove pathogenic granulocytes and macrophages that produce proinflammatory cytokines. The efficacy of GMA on PG has been reported, and treatment of PASHs with GMA has been described in a single case report

Successful treatment of pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome with granulocyte and monocyte adsorption apheresis – PubMed (nih.gov)