Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

Emilio Cuadrado ¹, Marta Alonso, Maria-Dolores de Juan, Pilar Echaniz, Juan-Ignacio Arenas, World J Gastroenterol. 2008 Mar 14;14(10):1521-7.

The clinical efficacy of GMA on IBD and related extra intestinal manifestations was associated with an expansion of circulating CD4+ CD25+ Tregs and higher expression of FoxP3 in CD4+ T cells. Accordingly, an elevated CD4+ CD25+ FoxP3 may be a valuable index of remission in patients with IBD and other chronic relapsing-remitting inflammatory conditions during treatment with GMA.

https://pubmed.ncbi.nlm.nih.gov/18330941/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693745/pdf/WJG-14-1521.pdf