Scientific corner

Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

Emilio Cuadrado 1Marta AlonsoMaria-Dolores de JuanPilar EchanizJuan-Ignacio Arenas, World J Gastroenterol. 2008 Mar 14;14(10):1521-7.

The clinical efficacy of GMA on IBD and related extra intestinal manifestations was associated with an expansion of circulating CD4+ CD25+ Tregs and higher expression of FoxP3 in CD4+ T cells. Accordingly, an elevated CD4+ CD25+ FoxP3 may be a valuable index of remission in patients with IBD and other chronic relapsing-remitting inflammatory conditions during treatment with GMA.

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