Emilio Cuadrado 1, Marta Alonso, Maria-Dolores de Juan, Pilar Echaniz, Juan-Ignacio Arenas, World J Gastroenterol. 2008 Mar 14;14(10):1521-7.
Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis
The clinical efficacy of GMA on IBD and related extra intestinal manifestations was associated with an expansion of circulating CD4+ CD25+ Tregs and higher expression of FoxP3 in CD4+ T cells. Accordingly, an elevated CD4+ CD25+ FoxP3 may be a valuable index of remission in patients with IBD and other chronic relapsing-remitting inflammatory conditions during treatment with GMA.
Crohn's disease / digestive / FoxP3+ T cells / immunology / MOA / Tregs / ulcerative colitis /
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