Yoshiharu Yamaguchi 1, Marie Nakagawa 1, Shoko Nakagawa 1, Kazuhiro Nagao 1, Satoshi Inoue 1, Tomoya Sugiyama 1, Shinya Izawa 1, Yasutaka Hijikata 1, Masahide Ebi 1, Yasushi Funaki 1, Naotaka Ogasawara 1, Makoto Sasaki 1, Kunio Kasugai 1 Intern Med 2021 Mar 1;60(5):725-730. doi: 10.2169/internalmedicine.5733-20. Epub 2020 Sep 30.
Scientific corner
Rapidly Progressing Aseptic Abscesses in a Patient with Ulcerative Colitis
Aseptic abscesses (AAs) are extraintestinal manifestations of inflammatory bowel disease (IBD). IBD-associated AAs are rare in Japan. We treated a 45-year-old man with ulcerative colitis (UC)-associated AAs. During remission, multiple progressive abscesses were detected in the spleen; he underwent splenectomy because an infectious disease was suspected. Although his condition improved temporarily after splenectomy, a large liver abscess was noted, and a diagnosis of UC-associated AAs was made. Granulocytapheresis (GCAP) and infliximab (IFX) administration resolved the abscess. This is the first reported case of UC-associated AAs in a Japanese patient treated by splenectomy, GCAP, and IFX.
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