Factors associated with treatment outcome, and long-term prognosis of patients with ulcerative colitis undergoing selective depletion of myeloid lineage leucocytes: a prospective multicenter study.

Selective myeloid leucocyte depletion was effective for remission induction and improving patients’ quality of life. Baseline demographics such as disease activity level, duration and corticosteroid dependency appear to predict response to GMA. Additionally, patients with a first UC episode who were drug naive responded well to GMA and achieved a favorable long-term disease course by avoiding pharmacologics from an early stage of their inflammatory bowel disease. These findings should help to end unnecessary use of medical resources by targeting GMA to patients who may respond well.

Yoko Yokoyama ¹, Kenji Watanabe ², Hiroaki Ito ³, Masakazu Nishishita ⁴, Koji Sawada ⁵, Yusuke Okuyama ⁶, Kazuichi Okazaki ⁷, Hisao Fujii ⁸, Hiroshi Nakase ⁹, Tsutomu Masuda ¹⁰, Ken Fukunaga ¹¹, Akira Andoh ¹², Shiro Nakamura ¹³ ,

Cytotherapy 2015 May;17(5):680-8. 

https://pubmed.ncbi.nlm.nih.gov/25804800/