Yoko Yokoyama 1, Ken Fukunaga 2, Koji Kamikozuru 2, Toshiyuki Sato 2, Mikio Kawai 2, Koji Nogami 2, Kazuko Nagase 2, Misaki Nakamura 2, Masaki Immured 2, Nobuyuki Hida 2, Shiro Nakamura 2 , Cytotherapy. 2014 Jun;16(6):821-5.
Crohn’s disease complicated by hepatitis B virus successfully treated with the use of adsorptive depletion of myeloid lineage leucocytes to suppress inflammatory cytokine profile.
Immunosuppressive therapy required to treat an active CD potentially can promote HBV reactivation and worsen liver function. In this study involving a CD case complicated by chronic HBV infection, intensive GMA as a non-pharmacologic treatment intervention was associated with clinical remission and endoscopic improvement without HBV reactivation. Furthermore, GMA was well-tolerated and was without any safety concern. However, suppression of tumor necrosis and interleukin-6by GMA in this clinical setting is potentially very interesting.
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