Crohn’s disease complicated by hepatitis B virus successfully treated with the use of adsorptive depletion of myeloid lineage leucocytes to suppress inflammatory cytokine profile.

Yoko Yokoyama ¹, Ken Fukunaga ², Koji Kamikozuru ², Toshiyuki Sato ², Mikio Kawai ², Koji Nogami ², Kazuko Nagase ², Misaki Nakamura ², Masaki Immured ², Nobuyuki Hida ², Shiro Nakamura ² , Cytotherapy. 2014 Jun;16(6):821-5.

Immunosuppressive therapy required to treat an active CD potentially can promote HBV reactivation and worsen liver function. In this study involving a CD case complicated by chronic HBV infection, intensive GMA as a non-pharmacologic treatment intervention was associated with clinical remission and endoscopic improvement without HBV reactivation. Furthermore, GMA was well-tolerated and was without any safety concern. However, suppression of tumor necrosis and interleukin-6by GMA in this clinical setting is potentially very interesting.

https://pubmed.ncbi.nlm.nih.gov/24713332/