Shin-ichiro Takeda 1, Toru Sato, Tatsuro Katsuno, Tomoo Nakagawa, Yoshiko Noguchi, Osamu Yokosuka, Yasushi Saito, Dig Dis Sci. 2010 Jul;55(7):1886-95.
Adsorptive depletion of α4 integrin(hi)- and CX3CR1(hi)-expressing proinflammatory monocytes in patients with ulcerative colitis
We found high expressions of alpha4 integrin and CX(3)CR1 on monocytes in patients with active UC, known to promote the extravasation of CD14(+)CD16(+) monocytes into the mucosa. GMA effectively depletes CD14(+)CD16(+) monocytes and concomitantly increases CD14(hi)CD16(-)CCR2(low) “immature” monocytes; thus GMA was associated with the emergence of less inflammatory monocyte phenotype in circulation.
CCR2 / CD14+ / CD16 / Cx3cr1 / immature monocytes; proinflammatory monocytes / immunology / other / α4 integrin /
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