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Treatment With Cytapheresis for Antineutrophil Cytoplasmic Antibody-associated Renal Vasculitis and Its Effect on Anti-inflammatory Factors

Midori Hasegawa 1Asako WatanabeHiroki TakahashiKazuo TakahashiMasami KasugaiNahoko KawamuraHiroko KushimotoKazutaka MurakamiMakoto TomitaKunihiro NabeshimaAtsushi OohashiFumiko KondouHisaji OoshimaYoshiyuki HikiSatoshi Sugiyama, Ther Apher Dial. 2005 Aug;9(4):297-302.

These results indicated that the mortality rate by infection could be reduced by adding cytapheresis therapy. Concerning the mechanism of cytapheresis, anti-inflammatory factors such as soluble tumor necrosis factor receptor, and interleukin-10 reduced after cytapheresis. These changes might be responsible for the efficacy of cytapheresis. In conclusion, cytapheresis is thought to be one of the effective treatments for RPGN caused by MPO-ANCA-associated vasculitis, reducing the levels of anti-inflammatory factors.

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