Midori Hasegawa 1, Asako Watanabe, Hiroki Takahashi, Kazuo Takahashi, Masami Kasugai, Nahoko Kawamura, Hiroko Kushimoto, Kazutaka Murakami, Makoto Tomita, Kunihiro Nabeshima, Atsushi Oohashi, Fumiko Kondou, Hisaji Ooshima, Yoshiyuki Hiki, Satoshi Sugiyama, Ther Apher Dial. 2005 Aug;9(4):297-302.
Treatment With Cytapheresis for Antineutrophil Cytoplasmic Antibody-associated Renal Vasculitis and Its Effect on Anti-inflammatory Factors
These results indicated that the mortality rate by infection could be reduced by adding cytapheresis therapy. Concerning the mechanism of cytapheresis, anti-inflammatory factors such as soluble tumor necrosis factor receptor, and interleukin-10 reduced after cytapheresis. These changes might be responsible for the efficacy of cytapheresis. In conclusion, cytapheresis is thought to be one of the effective treatments for RPGN caused by MPO-ANCA-associated vasculitis, reducing the levels of anti-inflammatory factors.
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