Takuro Kanekura 1, Mariko Seishima 2, Masaru Honma 3, Takafumi Etou 4, Hikaru Eto 5, Keiko Okuma 6, Yukari Okubo 7, Yukie Yamaguchi 8, Takeshi Kambara 9, Tomotaka Mabuchi 10, Yasushi Suga 11, Akimichi Morita 12, Kiyofumi Yamanishi 13, Daisuke Tsuruta 14, Kei Itoh 15, Ken Yamaji 16, Shigaku Ikeda 6 , J Dermatol. 2017 Dec;44(12):1353-1359.
Therapeutic depletion of myeloid lineage leukocytes by adsorptive apheresis for psoriatic arthritis: Efficacy of a non-drug intervention for patients refractory to pharmacologics.
This study demonstrates that GMA with the Adacolumn was effective with good safety profile in patients with PsA refractory to pharmacologicals. The results indicate a major role for myeloid leukocytes in the immunopathogenesis of PsA. A large controlled study is warranted to fully evaluate the efficacy of Adacolumn GMA in patients with PsA.
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