Scientific corner

Safety and efficacy of granulocyte/monocyte apheresis in steroid-dependent active ulcerative colitis with insufficient response or intolerance to immunosuppressants and/or biologics (ART trial): 12-week interim results.

Axel Dignass 1Ayesha Akbar 2Ailsa Hart 2Sreedhar Subramanian 3Gilles Bommelaer 4Daniel C Baumgart 5Jean-Charles Grimaud 6Guillaume Cadiot 7Richard Makins 8Syed Hoque 9Guillaume Bouguen 10Bruno Bonaz 11 , J Crohns Colitis. 2016 Jul;10(7):812-20. 

At Week 12, Adacolumn provided significant clinical benefit in a large cohort of steroid-dependent ulcerative colitis patients with previous failure to immunosuppressant and/or biologic treatment, with a favourable safety profile. These results are consistent with previous studies and support Adacolumn use in this difficult-to-treat patient subgroup.

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