K O Arseneau 1, F Cominelli, Dig Liver Dis. 2009 Aug;41(8):551-2.
Scientific corner
Leukocytapheresis in ulcerative colitis: a possible alternative to biological therapy?
In summary, selective adsorption of granulocytes and monocytes from the peripheral blood
of patients with active ulcerative colitis using the extracorporal Adacolumn GMA appears to
be an extremely safe treatment modality. Although conflicting results have been reported
regarding the efficacy of Adacolumn GMA, this study by Hibi et al. adds to the existing
literature by providing data from the largest population of ulcerative colitis patients yet to be
studied. If the observed treatment effect of 77.7% is representative of the true response rate,
Adacolumn GMA would be a safe alternative to biological therapies for patients with
refractory ulcerative colitis. In addition, granulocyte fractions could be used to help identify
patients who are most likely to benefit from this procedure
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