Scientific corner

Granulocytes and monocytes apheresis induces upregulation of TGFβ1 in patients with active ulcerative colitis: A possible involvement of soluble HLA-I.

Paola Contini 1, Simone Negrini 1, Giorgia Bodini 2, Cecilia Trucchi 3, Gianluca Ubezio 4, Paolo Strada 4, Vincenzo Savarino 2, Massimo Ghio 1, J Clin Apher. 2017 Feb;32(1):49-55.

 Taken together, these findings suggest that the immunosuppressive effects attributed to granulocyte and monocyte apheresis might depend, at least in part, on the sensitivity of activated leucocytes to the bioactivity of sHLA-I molecules.

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