Hiroyuki Hanai 1, Takayuki Iida, Masami Yamada, Yoshihiko Sato, Ken Takeuchi, Tatsuo Tanaka, Kenji Kondo, Masataka Kikuyama, Yasuhiko Maruyama, Yasushi Iwaoka, Akiko Nakamura, Kazuhisa Hirayama, Abby R Saniabadi, Fumitoshi Watanabe, World J Gastroenterol. 2006 Jun 7;12(21):3393-9.
Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis
We found strong correlations between CAI and IL-10 (r = 0.827, P < 0.001), IL-6 (r = 0.785, P < 0.001) and IL-18 (r = 0.791, P < 0.001). IL-1ra was not correlated with CAI. Following GMA therapy, 24 of the 31 patients achieved remission and the levels of all 4 cytokines fell to the levels in healthy controls. Further, blood levels of IL-1ra and IL-10 increased at the column outflow and inflow at 60 min suggesting release from leucocytes that adhered to the carriers.
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