Vladislaw Muratov 1, Ann-Kristin Ulfgren, Marianne Engström, Kerstin Elvin, Ola Winqvist, Robert Löfberg, Joachim Lundahl, J Gastroenterol. 2008;43(4):277-82.
Scientific corner
Decreased numbers of FoxP3-positive and TLR-2-positive cells in intestinal mucosa are associated with improvement in patients with active inflammatory bowel disease following selective leukocyte apheresis
Downregulation of FoxP3 and TLR-2 cells in the colorectal mucosa mirrors both short-and long-term improvement in patients with active IBD responding to GCAP. This observation suggests a potential role of these cells in the pathogenesis of IBD and the induction of immunological tolerance in the mucosa.
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