Scientific corner

Decreased numbers of FoxP3-positive and TLR-2-positive cells in intestinal mucosa are associated with improvement in patients with active inflammatory bowel disease following selective leukocyte apheresis

Vladislaw Muratov 1Ann-Kristin UlfgrenMarianne EngströmKerstin ElvinOla WinqvistRobert LöfbergJoachim Lundahl, J Gastroenterol. 2008;43(4):277-82.

Downregulation of FoxP3 and TLR-2 cells in the colorectal mucosa mirrors both short-and long-term improvement in patients with active IBD responding to GCAP. This observation suggests a potential role of these cells in the pathogenesis of IBD and the induction of immunological tolerance in the mucosa.

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