Yuriko Tsukada 1, Tetsuo Nakamura, Mitsutoshi Iimura, Bun-ei Iizuka, Naoaki Hayashi, Am J Gastroenterol. 2002 Nov;97(11):2820-8.
Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis
IL-8 mRNA was significantly increased in inflamed mucosa of UC. Patients with high IL-8 mRNA expression in colonic mucosa despite PSL treatment were responsive to GCAP. Therefore, quantitative measurement of mucosal IL-8 mRNA may be useful in predicting the response to GCAP.
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