Scientific corner

Cytapheresis for the treatment of myeloperoxidase antineutrophil cytoplasmic autoantibody-asociated vasculitis:A pilot study of 21 patients

Midori Hasegawa 1Atsushi OhashiNao KabutanSaori HiramatsuMasao KatoKazutaka MurakamiMakoto TomitaKunihiro NabeshimaYoshiyuki HikiSatoshi Sugiyama, Ther Apher Dial. 2006 Oct;10(5):412-8.

 From these results, cytapheresis can be considered a safe and effective treatment for MPO-ANCA-associated vasculitis. As for the mechanism of its action, soluble tumor necrosis factor receptor 1 (sTNFR), sTNFR2 and interleukin 1 receptor antagonist were elevated soon after cytapheresis and those levels 2 h after the cytapheresis procedure were higher than before the procedure in some cases. These elevations might be related to the efficacy of cytapheresis.

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