Adacolumn for selective leukocytapheresis as a non-pharmacological treatment for patients with disorders of the immune system: An adjunct or an alternative to drug therapy?

Abbi R. Saniabadi, Hiroyuki Hanai, Yasuo Suzuki, Toshihide Ohmori, Koji Sawada, Naoki Yoshimura, Yasushi Saito, Yuji Takeda, Kazuo Umemura, Kazunao Kondo, Yasuhiko Ikeda, Ken Fukunaga, Mitsuyoshi Nakashima, Alberto Beretta, Ingvar Bjarnason, Robert Lofberg, https://doi.org/10.1002/jca.20046

In conclusion, selective depletion of myeloid cells appears to induce anti-inflammatory effects and represents a non-pharmacological treatment for patients with active IBD. The treatment has a clear drug-sparing role. Changes in blood levels of inflammatory and anti-inflammatory factors are thought to contribute to the efficacy of this procedure.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.20046