Adacolumn® has been used in pregnant women in isolated cases or in short series of pregnant patients when the circumstances of their illness has required the use of some kind of treatment to rescue inflammatory activity. And in these pregnant women, the results of the intervention with Adacolumn® have been satisfactory in most cases and there have been no side effects either for the pregnant woman or for foetus, nor was there any effect on the outcome of the pregnancy.
References:
- Adacolumn® instructions for use.
- K. Yanagisawa, M. Murakami, Y. Kondo, et al.: Efficacy and Safety of Adsorptive Granulocyte and Monocyte Apheresis in Elderly and Pregnant Patients With Ulcerative Colitis Ther Apher Dial 2019 Jun;23(3):217-223.
- Y. Higashi 1, M. Shimokawa, K.Kawai, T. Kanekura, Granulocyte and monocyte adsorption apheresis for Behçet’s disease in a pregnant woman. J Dermatol. 2013 Dec;40(12):1042-4.
- H. Takahashi 1, K. Sugawara, M. Sugimura, et al.: Flare up of ulcerative colitis during pregnancy treated by adsorptive granulocyte and monocyte apheresis: therapeutic outcomes in three pregnant patients. Arch Gynecol Obstet. 2013 Aug;288(2):341-7.
- H Okada 1, C Makidono, R Takenaka, et al.: Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis. Digestion 2006;74(1):15-8.
- D’Ovidio V, Meo D, Gozer M, Bazuro ME, Vernia P. Ulcerative colitis and granulocyte-monocyte-apheresis: safety and efficacy of maintenance therapy during pregnancy. J Clin Apher. 2015 Feb;30(1):55-7.
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