Scientific corner

Granulocyte apheresis for pouchitis with arthritis and pyoderma gangrenosum after restorative proctocolectomy for ulcerative colitis: a case report

Ritsuko Yanaru-Fujisawa, Takayuki Matsumoto, Shotaro Nakamura, Shuji Kochi, Mitsuo Iida, Futoshi Kohda, Minako Hirahashi, Takashi Yao, Ryuichi Case Reports Inflamm Bowel Dis. 2005 Aug;11(8):780 DOI: 10.1097/01.mib.0000172558.39767.b7

Our case and the case of Kanekura et al8 suggest that circulating leukocytes may play an important role in the pathogenesis of PG and that GCAP in combination with corticosteroids may be a promising strategy for intractable PG. Furthermore, as has been the case for active UC, GCAP may be a choice for severe pouchitis. An accumulation of data with respect to the effect of GCAP on pouchitis seems to be warranted.

https://pubmed.ncbi.nlm.nih.gov/16043996/

https://academic.oup.com/ibdjournal/article/11/8/780/4685895

Scientific corner

Efficacy of granulocytapheresis and leukocytapheresis for the treatment of microscopic polyangiitis

Midori Hasegawa 1, Nahoko Kawamura, Masamitsu Murase, Shigehisa Koide, Hiroko Kushimoto, Kazutaka Murakami, Makoto Tomita, Yoshiyuki Hiki, Masahiko Shikano, Satoshi Sugiyama, Ther Apher Dial. 2004 Jun;8(3):212-6.

We concluded that combined therapy of GCAP or LCAP and corticosteroids is effective for the treatment of RPGN and lung hemorrhage due to microscopic polyangiitis.

https://pubmed.ncbi.nlm.nih.gov/15154873/

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