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PP2-05 Clinical factors associated with relapse of ulcerative colitis after granulocyte-monocyte adsorption

poster at ISFA 2019 pag 155

Clinical factors correlated with early relapse of ulcerative colitis (UC) after granulocytemonocyte adsorption (GMA) were investigated. The data from 61 UC patients treated by a
series of 10 sessions of GMA were collected retrospectively. UC was relapsed in 14 patients
(23%) within 24 weeks after GMA. Compared with non-relapse group, relapse group had
significantly higher value of Seo index (SI) evaluated before and after GMA treatment.
Binomial logistic regression analysis showed that SI was significantly correlated with UC
relapse. Relapse rate was significantly different between groups divided according to SI. Seo
index may associated with early relapse of UC.

http://www.atalacia.com/isfa/data/abstract.pdf

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Looking for predictive factors of clinical response to adsorptive granulocyte and monocyte apheresis in patients with ulcerative colitis: markers of response to GMA.

Yoko Yokoyama, Mikio Kawai, Ken Fukunaga, Koji Kamikozuru, Kazuko Nagase, Koji Nogami, Tomoaki Kono,Yoshio Ohda, Masaki Iimuro, Nobuyuki Hida, Shiro Nakamura, Hiroto Miwa and Takayuki Matsumoto, Yokoyama et al. BMC Gastroenterology 2013

In this study, patients with a short duration of UC and low cumulative PSL dose seemed to respond well to GMA. However, we found that the best responders were patients who received GMA immediately after a clinical relapse. Additionally, GMA was effective in patients with low WBC count at the first GMA session. The findings of this study should spare medical cost and reduce morbidity time for many patients, relevant for decision making in clinical settings.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583683/pdf/1471-230X-13-27.pdf

https://pubmed.ncbi.nlm.nih.gov/23399416/

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Predictive factors of clinical response in steroid-refractory ulcerative colitis treated with granulocyte-monocyte apheresis

Valeria D’Ovidio 1Donatella MeoAngelo ViscidoGiampaolo BresciPiero VerniaRenzo Caprilli, World J Gastroenterol. 2011 Apr 14;17(14):1831-5.

GMA may be a valid therapeutic option for steroid-dependent ulcerative colitis patients with mild-moderate disease and its clinical efficacy seems to persist for 12 months.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080717/pdf/WJG-17-1831.pdf

https://pubmed.ncbi.nlm.nih.gov/21528055/

Scientific corner

Treating ulcerative colitis by Adacolumn therapeutic leucocytapheresis: clinical efficacy and safety based on surveillance of 656 patients in 53 centres in Japan

T Hibi 1Y SameshimaY SekiguchiY HisatomeF MaruyamaK MoriwakiC ShimaA R SaniabadiT Matsumoto

Dig Liver Dis. 2009 Aug;41(8):570-7. doi: 10.1016/j.dld.2008.11.020. Epub 2009 Feb 10.

Background/aim: The Adacolumn selectively depletes granulocytes and monocytes/macrophages, which are thought to be part of the immunopathogenesis of ulcerative colitis. This work aims at evaluating the safety and clinical efficacy of the Adacolumn in patients with ulcerative colitis in large population-based data sets. Methods: The Adacolumn post marketing surveillance in Japan was undertaken on 697 patients in 53 medical institutions over 7 years from 29 October 1999 to 28 October 2006. Clinical efficacy and safety data were provided by patients’ physicians in the participating institutes. Results: Safety was evaluated in all the 697 patients and efficacy in 656 patients. At entry, 92% of the patients were on salicylates, 74% on prednisolone and only 9% on immunomodulators. Approximately 40% of patients had severe ulcerative colitis and over 70% had ulcerative colitis that was refractory to conventional medications. There was no serious adverse events; mild to moderate adverse events were seen in 7.7% of the patients. The overall response (remission or significantly improved) was 77.3%; the remission rate based on clinical activity index was 71.1%, while 17.1% remained unchanged and 5.6% worsened. Patients were subgrouped into severe, moderate and mild ulcerative colitis based on clinical activity index (n=578), the response rates were 63.2%, 65.7% and 80.4%, respectively (P<0.001). Endoscopic assessment of efficacy showed very significant mucosal healing, Matts’ endoscopic index improved from 3.2+/-0.04 to 2.1+/-0.7 (n=219, P<0.001); reduction in prednisolone dose (P<0.0001); leucocyte count (n=358, P<0.0001) and C-reactive protein (n=314, P<0.0001). Patients who received > or =6 Adacolumn sessions (n=319) did better than patients who received < or =5 sessions (n=188, P=0.004) and multivariate logistic regression analysis revealed that baseline granulocyte count was the strongest predictor of clinical response to Adacolumn (P=0.0191, odds ratio 1.151). Conclusion: This post marketing surveillance provides the largest ever efficacy and safety data on the Adacolumn therapeutic leucocytapheresis in patients with ulcerative colitis. As a non-pharmacologic treatment for patients with active ulcerative colitis most of whom were refractory to conventional drug therapy, the observed efficacy was very significant. Baseline granulocyte count was convincingly an independent predictor of clinical response.

https://pubmed.ncbi.nlm.nih.gov/19211314/

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