Eugeni Domènech 1, Julián Panés 2, Joaquín Hinojosa 3, Vito Annese 4, Fernando Magro 5, Giacomo Carlo Sturniolo 6, Fabrizio Bossa 7, Francisco Fernández 8, Benito González-Conde 9, Valle García-Sánchez 10, Axel Dignass 11, José Manuel Herrera 12, José Luis Cabriada 13, Jordi Guardiola 14, Maurizio Vecchi 15, Francisco Portela 16, Daniel Ginard 17, J Crohns Colitis. 2018 May 25;12(6):687-694.
Addition of granulocyte/monocyte apheresis to oral prednisone for steroid-dependent ulcerative colitis: A randomized, multicentre, clinical trial.
In a randomized trial, the addition of 7 weekly sessions of GMA to a conventional course of oral prednisone did not increase the proportion of steroid-free remissions in patients with active steroid-dependent UC, though it delayed clinical relapse.
Efficacy of granulocyte and monocyte apheresis for antibiotic-refractory pouchitis after proctocolectomy for ulcerative colitis: an open-label, prospective, multicentre study
GMA has a good safety profile, but its efficacy appears to be limited in the management of chronic refractory pouchitis. However, a large controlled study should be conducted to evaluate the efficacy of GMA therapy in patients with pouchitis at an earlier clinical stage, before the disease has become refractory to conventional medical therapy.
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