Selective myeloid leucocyte depletion was effective for remission induction and improving patients’ quality of life. Baseline demographics such as disease activity level, duration and corticosteroid dependency appear to predict response to GMA. Additionally, patients with a first UC episode who were drug naive responded well to GMA and achieved a favorable long-term disease course by avoiding pharmacologics from an early stage of their inflammatory bowel disease. These findings should help to end unnecessary use of medical resources by targeting GMA to patients who may respond well.
Factors associated with treatment outcome, and long-term prognosis of patients with ulcerative colitis undergoing selective depletion of myeloid lineage leucocytes: a prospective multicenter study.
Yoko Yokoyama 1, Kenji Watanabe 2, Hiroaki Ito 3, Masakazu Nishishita 4, Koji Sawada 5, Yusuke Okuyama 6, Kazuichi Okazaki 7, Hisao Fujii 8, Hiroshi Nakase 9, Tsutomu Masuda 10, Ken Fukunaga 11, Akira Andoh 12, Shiro Nakamura 13 ,
Cytotherapy 2015 May;17(5):680-8.
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