Scientific corner

Effectiveness of Cytapheresis for Ulcerative Colitis in Special Situations: Delayed Onset of Optimum Efficacy in Elderly Patients

Tomoyoshi Shibuya 1Osamu Nomura 2Kei Nomura 2Koki Okahara 2Keiichi Haga 2Dai Ishikawa 2Naoto Sakamoto 2Tatsuo Ogihara 2Taro Osada 2Akihito Nagahara 2 , Digestion, 2020;101(1):46-52. 

Unlike pharmacologicals, the efficacy of Cytapheresis appears to be time dependent. Accordingly, in the elderly, we observed a delayed response, indicating that elderly patients may respond beyond the end of Cytapheresis therapy. Therefore, patients who do not show efficacy at the end of Cytapheresis therapy should be followed up for delayed response. Further, Cytapheresis is favored by patients for its good safety profile.

https://pubmed.ncbi.nlm.nih.gov/31722366/

Scientific corner

An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn’s disease.

Atsushi Sakuraba 1Satoshi MotoyaKenji WatanabeMasakazu NishishitaKazunari KankeToshiyuki MatsuiYasuo SuzukiTadayuki OshimaReiko KunisakiTakayuki MatsumotoHiroyuki HanaiKen FukunagaNaoki YoshimuraToshimi ChibaShinsuke FunakoshiNobuo AoyamaAkira AndohHiroshi NakaseYohei MizutaRyoichi SuzukiTaiji AkamatsuMasahiro IizukaToshifumi AshidaToshifumi Hibi, Am J Gastroenterol. 2009 Dec;104(12):2990-5.

Intensive GMA in patients with active UC seems to be more efficacious than weekly treatment, and significantly reduced the patients’ morbidity time without increasing the incidence of side effects.

https://pubmed.ncbi.nlm.nih.gov/19724269/

Scientific corner

Mucosal healing of esophageal involvement of Crohn’s disease with granulocyte/monocyte adsorption

Kosaku Moribata 1Jun KatoSae IimuraSatoshi YoshidaNaoki ShingakiKazuki UedaHisanobu DeguchiIzumi InoueTakao MaekitaMikitaka IguchiHideyuki TamaiMasao Ichinose, J Clin Apher. 2011;26(4):225-7.

We report a case of a 16-year-old male who suffered from Crohn’s disease (CD) with esophageal involvement, showing remarkable improvement with granulocyte/monocyte adsorption (GMA). The patient had been diagnosed as ileocolic CD and was treated with 5-aminosalicylate. He was admitted to our hospital with symptoms of fever, diarrhea, and odynophagia. Endoscopic examinations revealed that the exacerbation of ileocolic ulcers, and advent of ulcers in esophagus. Because of the patient’s refusal to receive corticosteroids, immunomodulators, or biologics, he underwent GMA twice a week. After 10 sessions of GMA, he entered remission with significant decrease in clinical activity. In addition, endoscopic examinations showed remarkable improvement of ileocolic ulcers and disappearance of esophageal lesions. No adverse events were observed. GMA could be effective for manifestations of CD in gastrointestinal tract other than ileum or colon.

https://pubmed.ncbi.nlm.nih.gov/21786316/

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