Sequential therapy consisting of glucocorticoid infusions followed by granulocyte-monocyte absorptive apheresis in patients with severe alcoholic hepatitis.

Kazuhiro Watanabe¹, Yoshihito Uchida¹, Kayoko Sugawara¹, Kayoko Naiki¹, Mie Inao¹, Nobuaki Nakayama¹, Satoshi Mochida² , J Gastroenterol 2017 Jul;52(7):830-837.

Sequential therapy combining glucocorticoid infusion and GMA was useful for attenuating liver injuries in patients with severe alcoholic hepatitis by preventing rebound increases in inflammatory reactions after discontinuation of glucocorticoid infusions, except in patients with bacterial infections and/or multiple organ failure.

https://pubmed.ncbi.nlm.nih.gov/27858246/

Alcoholic hepatitis / combination / cytokines / digestive / Glucocorticoid / immunology /

Scientific corner

2016

Adacolumn Granulocyte-Apheresis for Alcoholic Hepatitis: Preliminary Study

V Morabito¹, S Novelli², L Poli³, G Ferretti⁴, F Ruberto⁵, F Pugliese⁵, R Pretagostini³, P B Berloco³, M Rossi³ , Transplant Proc. 2016 Mar;48(2):352-8.

The Adacolumn apheresis was safe and was able to determine an improvement of clinical status of patients with reduction of inflammatory markers. More patients are needed to validate these results.

https://pubmed.ncbi.nlm.nih.gov/27109954/

Alcoholic hepatitis / Clinical remission / nephrology /

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