Scientific corner

Sequential therapy consisting of glucocorticoid infusions followed by granulocyte-monocyte absorptive apheresis in patients with severe alcoholic hepatitis.

Kazuhiro Watanabe 1Yoshihito Uchida 1Kayoko Sugawara 1Kayoko Naiki 1Mie Inao 1Nobuaki Nakayama 1Satoshi Mochida 2 , J Gastroenterol 2017 Jul;52(7):830-837.

Sequential therapy combining glucocorticoid infusion and GMA was useful for attenuating liver injuries in patients with severe alcoholic hepatitis by preventing rebound increases in inflammatory reactions after discontinuation of glucocorticoid infusions, except in patients with bacterial infections and/or multiple organ failure.

Scientific corner

Adacolumn Granulocyte-Apheresis for Alcoholic Hepatitis: Preliminary Study

V Morabito 1S Novelli 2L Poli 3G Ferretti 4F Ruberto 5F Pugliese 5R Pretagostini 3P B Berloco 3M Rossi 3 , Transplant Proc. 2016 Mar;48(2):352-8.

The Adacolumn apheresis was safe and was able to determine an improvement of clinical status of patients with reduction of inflammatory markers. More patients are needed to validate these results.

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