Shoichi Nishise ^1 2, Yuji Takeda ³, Yasuhiko Abe ¹, Yu Sasaki ¹, Shinichi Saitoh ³, Hidetoshi Nara ³, Hironobu Asao ³, Yoshiyuki Ueno, Ther Apher Dial 2020 Oct 17.

These results indicated that physiological heating of the apheresis carrier augmented the anti-inflammatory reaction in vitro. Thus, heating during GMA may be a new approach for augmenting clinical efficacy.

https://pubmed.ncbi.nlm.nih.gov/33067913/

Shoichi Nishise ¹, Yuji Takeda ², Hidetoshi Nara ², Yasuhiko Abe ¹, Yu Sasaki ¹, Hironobu Asao ², Yoshiyuki Ueno ¹ , Ther Apher Dial. 2018 Jun;22(3):261-265.

These results suggest that independent of incubation temperature, sICAM-1 and sVCAM-1 are likely to adsorb CA beads. These molecules may be a new index for predicting the therapeutic effects of GMA.

https://pubmed.ncbi.nlm.nih.gov/29745046/

Shuai Ma ¹, Qingqing Xu ¹, Bo Deng ¹, Yin Zheng ², Hongyan Tian ¹, Li Wang ³, Feng Ding ⁴ , Intensive Care Med Exp. 2017 Dec;5(1):18.

This study showed that selective granulocyte and monocyte adsorption with cellulose acetate beads might ameliorate cecal ligation and puncture (CLP)-induced sepsis and improve survival and organ function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366986/pdf/40635_2017_Article_129.pdf

https://pubmed.ncbi.nlm.nih.gov/28342161/

Shoichi Nishise ¹, Yuji Takeda ², Yasuhiko Abe ¹, Yu Sasaki ¹, Hidetoshi Nara ², Hironobu Asao ², Yoshiyuki Ueno ¹ , Ther Apher Dial. 2017 Jun;21(3):248-254.

These results suggest that warming the column during GMA might increase GM adsorption to CA beads, thereby enhancing the clinical efficacy of GMA.

https://pubmed.ncbi.nlm.nih.gov/28661094/

Shoichi Nishise ¹, Yasuhiko Abe ¹, Eiki Nomura ², Takeshi Sato ¹, Yu Sasaki ¹, Daisuke Iwano ¹, Kazuya Yoshizawa ¹, Makoto Yagi ¹, Kazuhiro Sakuta ¹, Yoshiyuki Ueno ¹ , Ther Apher Dial. 2016 Aug;20(4):354-9.

 In conclusion, CA beads inhibited IL-23 release from adsorbed GMs. The biological effects of this decrease in IL-23 release during GM adsorption to CA beads need further clarification.

https://pubmed.ncbi.nlm.nih.gov/27523075/

Shoichi Nishise ¹, Yasuhiko Abe ¹, Eiki Nomura ¹, Takeshi Sato ¹, Yu Sasaki ¹, Daisuke Iwano ¹, Makoto Yagi ¹, Kazuhiro Sakuta ¹, Rika Shibuya ¹, Naoko Mizumoto ¹, Nana Kanno ¹, Yoshiyuki Ueno ¹ , Ther Apher Dial. 2015 Aug;19(4):330-5.

In conclusion, CA beads inhibited the release of TGF-β from adsorbed platelets. The biological effects of this reduction of TGF-β release during platelet adsorption to CA beads need further clarification.

https://pubmed.ncbi.nlm.nih.gov/26386220/

Shoichi Nishise ¹, Yasuhiko Abe, Eiki Nomura, Takeshi Sato, Yu Sasaki, Daisuke Iwano, Kazuya Yoshizawa, Makoto Yagi, Yuko Nishise, Yoshiyuki Ueno, Ther Apher Dial. 2014 Jun;18(3):252-7.

umor necrosis factor-α, (TNF)-α, a proinflammatory cytokine, is produced by activated granulocytes and monocytes (GMs) and implicated as a major factor in inflammatory bowel disease (IBD) pathogenesis. Reduction of TNF-α should improve IBD pathology. GM adsorptive apheresis (GMA) is an effective therapy for inflammatory disorders including IBD. GM adsorption to cellulose acetate (CA) beads induces anti-inflammatory cytokine release, although these effects on TNF-α release are not clarified. We hypothesized that GMA may inhibit TNF-α release. The aim of the present study was to clarify the effects of GM adsorption to CA beads on TNF-α release in vitro. Peripheral blood was incubated with and without CA beads and TNF-α was measured. For comparison, TNF-α was measured in another lipopolysaccharide (LPS)-containing peripheral blood sample incubated similarly. The amount of TNF-α in blood samples incubated with CA beads was significantly higher than in those incubated without beads, although it was significantly lower than TNF-α incubated with LPS-containing sample without beads. The amount of TNF-α after incubation with CA beads positively correlated with GM adsorption ratio. GM adsorption to CA beads induced a small amount of TNF-α release. This is the first report on TNF-α release induced via GM adsorption stimuli. The biological effects of TNF-α release during GM adsorption need to be clarified.

https://pubmed.ncbi.nlm.nih.gov/24965291/

Shoichi Nishise ¹, Yu Sasaki, Yoshiyuki Ueno, Ther Apher Dial. 2013 Oct;17(5):564-5.

https://pubmed.ncbi.nlm.nih.gov/24107285/

Yuko Higashi ¹, Mitsuyoshi Shimokawa, Kazuhiro Kawai, Takuro Kanekura, J Dermatol. 2013 Dec;40(12):1042-4.

We present a 39-year-old pregnant woman with Behçet’s disease who was treated successfully with granulocyte and monocyte adsorption apheresis (GMA). There were no complications or adverse effects during her pregnancy and delivery. The neonate manifested no abnormalities.

https://pubmed.ncbi.nlm.nih.gov/24303809/