{"id":9972,"date":"2024-03-14T14:03:24","date_gmt":"2024-03-14T13:03:24","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=9972"},"modified":"2024-03-27T14:10:20","modified_gmt":"2024-03-27T13:10:20","slug":"mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/","title":{"rendered":"Mathematical modeling in autoimmune diseases: from theory to clinical application"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">Yaroslav Ugolkov, Antonina Nikitich, Cristina Leon,Gabriel Helmlinger, Kirill Peskov, Victor Sokolov, Alina Volkova, Front. Immunol. 2024, 15:1371620.doi: 10.3389\/fimmu.2024.1371620<\/p>\n<p>The research &#038; development (R&#038;D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. The number of targeted therapies available on the market is limited, whereas the prevalence of autoimmune conditions in the global population continues to rise. Mathematical modeling of biological systems is an essential tool which may be applied in support of decision-making across R&#038;D drug programs to improve the probability of success in the development of novel medicines. Over the past decades, multiple models of autoimmune diseases have been developed. Models differ in the spectra of quantitative data used in their development and mathematical methods, as well as in the level of \u201cmechanistic granularity\u201d chosen to describe the underlying biology. Yet, all models strive towards the same goal: to quantitatively describe various aspects of the immune response. The aim of this review was to conduct a systematic review and analysis of mathematical models of autoimmune diseases focused on the mechanistic description of the immune system, to consolidate existing quantitative knowledge on autoimmune processes, and to outline potential directions of interest for future model-based analyses. Following a systematic literature review, 38 models describing the onset, progression, and\/or the effect of treatment in 13 systemic and organ-specific autoimmune conditions were identified, most models developed for inflammatory bowel disease, multiple sclerosis, and lupus (5 models each). \u226570% of the models were developed as nonlinear systems of ordinary differential equations, others \u2013 as partial differential equations, integro-differential equations, Boolean networks, or probabilistic models. Despite covering a relatively wide range of diseases, most models described the same components of the immune system, such as T-cell response, cytokine influence, or the involvement of macrophages in autoimmune processes. All models were thoroughly analyzed with an emphasis on assumptions, limitations, and their potential applications in the development of novel medicines.\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Yaroslav Ugolkov, Antonina Nikitich, Cristina Leon,Gabriel Helmlinger, Kirill Peskov, Victor Sokolov, Alina Volkova, Front. Immunol. 2024, 15:1371620.doi: 10.3389\/fimmu.2024.1371620 The research &#038; development (R&#038;D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. The number of targeted therapies available on the market is [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[456,424,426,805,183],"class_list":["post-9972","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-autoimmune-disease","scientific_tags-gma","scientific_tags-ibd","scientific_tags-mathematical-modellng","scientific_tags-tnf-"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mathematical modeling in autoimmune diseases: from theory to clinical application - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mathematical modeling in autoimmune diseases: from theory to clinical application - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Yaroslav Ugolkov, Antonina Nikitich, Cristina Leon,Gabriel Helmlinger, Kirill Peskov, Victor Sokolov, Alina Volkova, Front. Immunol. 2024, 15:1371620.doi: 10.3389\/fimmu.2024.1371620 The research &#038; development (R&#038;D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. The number of targeted therapies available on the market is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-27T13:10:20+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/\",\"name\":\"Mathematical modeling in autoimmune diseases: from theory to clinical application - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-03-14T13:03:24+00:00\",\"dateModified\":\"2024-03-27T13:10:20+00:00\",\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mathematical modeling in autoimmune diseases: from theory to clinical application - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/mathematical-modeling-in-autoimmune-diseases-from-theory-to-clinical-application\/","og_locale":"fr_FR","og_type":"article","og_title":"Mathematical modeling in autoimmune diseases: from theory to clinical application - Adacyte","og_description":"Yaroslav Ugolkov, Antonina Nikitich, Cristina Leon,Gabriel Helmlinger, Kirill Peskov, Victor Sokolov, Alina Volkova, Front. Immunol. 2024, 15:1371620.doi: 10.3389\/fimmu.2024.1371620 The research &#038; development (R&#038;D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. 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