{"id":8552,"date":"2020-09-17T13:37:00","date_gmt":"2020-09-17T13:37:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=8552"},"modified":"2024-05-02T10:22:35","modified_gmt":"2024-05-02T08:22:35","slug":"novel-prognostic-biomarkers-of-mucosal-healing-in-ulcerative-colitis-patients-treated-with-anti-tnf-neutrophil-tolymphocyte-ratio-and-platelet-to-lymphocyte-ratio","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/novel-prognostic-biomarkers-of-mucosal-healing-in-ulcerative-colitis-patients-treated-with-anti-tnf-neutrophil-tolymphocyte-ratio-and-platelet-to-lymphocyte-ratio\/","title":{"rendered":"Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated With Anti-TNF: Neutrophil-toLymphocyte Ratio and Platelet-to-Lymphocyte Ratio"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bertani+L&amp;cauthor_id=32232392\">Lorenzo Bertani<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rossari+F&amp;cauthor_id=32232392\">Federico Rossari<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Barberio+B&amp;cauthor_id=32232392\">Brigida Barberio<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Demarzo+MG&amp;cauthor_id=32232392\">Maria Giulia Demarzo<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tapete+G&amp;cauthor_id=32232392\">Gherardo Tapete<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Albano+E&amp;cauthor_id=32232392\">Eleonora Albano<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Baiano+Svizzero+G&amp;cauthor_id=32232392\">Giovanni Baiano Svizzero<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ceccarelli+L&amp;cauthor_id=32232392\">Linda Ceccarelli<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mumolo+MG&amp;cauthor_id=32232392\">Maria Gloria Mumolo<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Brombin+C&amp;cauthor_id=32232392\">Chiara Brombin<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=de+Bortoli+N&amp;cauthor_id=32232392\">Nicola de Bortoli<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bellini+M&amp;cauthor_id=32232392\">Massimo Bellini<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Marchi+S&amp;cauthor_id=32232392\">Santino Marchi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bodini+G&amp;cauthor_id=32232392\">Giorgia Bodini<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Savarino+E&amp;cauthor_id=32232392\">Edoardo Savarino<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Costa+F&amp;cauthor_id=32232392\">Francesco Costa<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/#affiliation-5\">5<\/a><\/sup><\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Inflamm Bowel Dis.\u00a02020 Sep 18;26(10):1579-1587.\u00a0doi: 10.1093\/ibd\/izaa062.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background:\u00a0<\/strong>Anti-tumor necrosis factor drugs (anti-TNFs) are widely used for the treatment of ulcerative colitis (UC). However, many patients experience loss of response during the first year of therapy. An early predictor of clinical remission and mucosal healing is needed. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of subclinical inflammation poorly evaluated in UC patients treated with anti-TNFs. The aim of this multicenter study was to evaluate whether NLR and PLR could be used as prognostic markers of anti-TNF treatment response. <strong>Methods:\u00a0<\/strong>Patients with UC who started anti-TNF treatment in monotherapy were evaluated. Patients with concomitant corticosteroid treatment \u226520 mg were excluded. We calculated NLR, PLR, and fecal calprotectin before treatment and after induction. The values of NLR and PLR were correlated with clinical remission and mucosal healing at the end of follow-up (54 weeks) using the Mann-Whitney U test and then multivariate analysis was conducted. <strong>Results:\u00a0<\/strong>Eighty-eight patients were included. Patients who reached mucosal healing after 54 weeks of therapy displayed lower levels of both baseline NLR and PLR (P = 0.0001 and P = 0.04, respectively); similar results were obtained at week 8 (P = 0.0001 and P = 0.001, respectively). Patients who presented with active ulcers at baseline endoscopic evaluation had higher baseline NLR and PLR values compared with those without detected ulcers (P = 0.002 and P = 0.0007, respectively). <strong>Conclusions:\u00a0<\/strong>Both NLR and PLR showed a promising role as early predictors of therapeutic response to anti-TNF therapy in UC patients. If confirmed in larger studies, classification and regression trees proposed in this article could be useful to guide clinical decisions regarding anti-TNF treatment.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32232392\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Lorenzo Bertani\u00a01,\u00a0Federico Rossari\u00a02,\u00a0Brigida Barberio\u00a03,\u00a0Maria Giulia Demarzo\u00a04,\u00a0Gherardo Tapete\u00a01,\u00a0Eleonora Albano\u00a01,\u00a0Giovanni Baiano Svizzero\u00a01,\u00a0Linda Ceccarelli\u00a05,\u00a0Maria Gloria Mumolo\u00a05,\u00a0Chiara Brombin\u00a06,\u00a0Nicola de Bortoli\u00a01,\u00a0Massimo Bellini\u00a01,\u00a0Santino Marchi\u00a01,\u00a0Giorgia Bodini\u00a04,\u00a0Edoardo Savarino\u00a03,\u00a0Francesco Costa\u00a05 Inflamm Bowel Dis.\u00a02020 Sep 18;26(10):1579-1587.\u00a0doi: 10.1093\/ibd\/izaa062. Background:\u00a0Anti-tumor necrosis factor drugs (anti-TNFs) are widely used for the treatment of ulcerative colitis (UC). However, many patients experience loss of response during the first year of therapy. [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[92,144,147,708,654,424,434,308,655,707],"class_list":["post-8552","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-anti-tnf","scientific_tags-biomarker","scientific_tags-clinical-remission","scientific_tags-early-predictors","scientific_tags-fecal-calprotectin","scientific_tags-gma","scientific_tags-loss-of-response","scientific_tags-mucosal-healing","scientific_tags-nlr","scientific_tags-plr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated With Anti-TNF: Neutrophil-toLymphocyte Ratio and Platelet-to-Lymphocyte Ratio - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/novel-prognostic-biomarkers-of-mucosal-healing-in-ulcerative-colitis-patients-treated-with-anti-tnf-neutrophil-tolymphocyte-ratio-and-platelet-to-lymphocyte-ratio\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated With Anti-TNF: Neutrophil-toLymphocyte Ratio and Platelet-to-Lymphocyte Ratio - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Lorenzo Bertani\u00a01,\u00a0Federico Rossari\u00a02,\u00a0Brigida Barberio\u00a03,\u00a0Maria Giulia Demarzo\u00a04,\u00a0Gherardo Tapete\u00a01,\u00a0Eleonora Albano\u00a01,\u00a0Giovanni Baiano Svizzero\u00a01,\u00a0Linda Ceccarelli\u00a05,\u00a0Maria Gloria Mumolo\u00a05,\u00a0Chiara Brombin\u00a06,\u00a0Nicola de Bortoli\u00a01,\u00a0Massimo Bellini\u00a01,\u00a0Santino Marchi\u00a01,\u00a0Giorgia Bodini\u00a04,\u00a0Edoardo Savarino\u00a03,\u00a0Francesco Costa\u00a05 Inflamm Bowel Dis.\u00a02020 Sep 18;26(10):1579-1587.\u00a0doi: 10.1093\/ibd\/izaa062. Background:\u00a0Anti-tumor necrosis factor drugs (anti-TNFs) are widely used for the treatment of ulcerative colitis (UC). However, many patients experience loss of response during the first year of therapy. 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Background:\u00a0Anti-tumor necrosis factor drugs (anti-TNFs) are widely used for the treatment of ulcerative colitis (UC). However, many patients experience loss of response during the first year of therapy. 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