{"id":6845,"date":"2006-11-09T10:36:00","date_gmt":"2006-11-09T10:36:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6845"},"modified":"2022-04-01T11:47:49","modified_gmt":"2022-04-01T11:47:49","slug":"efficacy-of-granulocyte-apheresis-in-pediatric-patients-with-ulcerative-colitis-a-pilot-study","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/efficacy-of-granulocyte-apheresis-in-pediatric-patients-with-ulcerative-colitis-a-pilot-study\/","title":{"rendered":"Efficacy of Granulocyte Apheresis in Pediatric Patients With\u00a0Ulcerative Colitis: A Pilot Study"},"content":{"rendered":"
\n

Ikeda, Hitoshi; Ishimaru, Yuki; Takayasu, Hajime; Fujino, Junko; Kisaki, Yoshiyuki; Otani, Yushi; Yamagishi, Junko; Tahara, Kazunori. J Pediatr Gastroenterol Nutr 2006; 43:592-6. doi: 10.1097\/01.mpg.0000237928.07729.79<\/p>\n<\/div>\n\n

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Objectives: <\/strong>Granulocyte apheresis (GCAP), involving the removal of granulocytes from the blood, may improve clinical symptoms and facilitate a reduction in the dose of steroids in adult patients with ulcerative colitis. As a preliminary trial, GCAP was used to taper the dose of steroids in 4 pediatric patients with ulcerative colitis. Methods:<\/strong> Three males and 1 female ranging from 11 to 17 years old were treated with GCAP once per week for 5 consecutive weeks\/course. The ages of patients at clinical onset ranged from 8 to 12 years and the length of time from the clinical onset to GCAP treatment ranged from 28 to 58 months (median, 38.5 months). Results:<\/strong> In 2 patients, symptoms and signs indicating disease activity improved after 2 courses of GCAP. Laboratory data and endoscopic findings also improved after treatment and the clinical efficacy was judged to be excellent in these patients. In 1 patient, GCAP improved laboratory and endoscopic hallmarks, but bloody stools persisted. Finally, the treatment was ineffective in the fourth patient who eventually underwent surgery. Conclusions:<\/strong> GCAP is effective in improving clinical symptoms and may play an important role in converting steroid therapy to other treatments in children with steroid-refractory or steroid-dependent ulcerative colitis.<\/p>\n<\/div>\n\n

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https:\/\/journals.lww.com\/jpgn\/FullText\/2006\/11000\/Efficacy_of_Granulocyte_Apheresis_in_Pediatric.8.aspx<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Ikeda, Hitoshi; Ishimaru, Yuki; Takayasu, Hajime; Fujino, Junko; Kisaki, Yoshiyuki; Otani, Yushi; Yamagishi, Junko; Tahara, Kazunori. J Pediatr Gastroenterol Nutr 2006; 43:592-6. doi: 10.1097\/01.mpg.0000237928.07729.79 Objectives: Granulocyte apheresis (GCAP), involving the removal of granulocytes from the blood, may improve clinical symptoms and facilitate a reduction in the dose of steroids in adult patients with ulcerative colitis. As a […]<\/p>\n","protected":false},"template":"","scientific_tags":[588,601,424,405,313,174,156,523,55,135,274,306,500],"class_list":["post-6845","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-response","scientific_tags-endoscopic-response","scientific_tags-gma","scientific_tags-pediatric","scientific_tags-pediatry","scientific_tags-pilot-study","scientific_tags-safety","scientific_tags-steroid-tapering","scientific_tags-steroid-dependent","scientific_tags-steroid-refractory","scientific_tags-symptoms-efficay","scientific_tags-ulcerative-colitis","scientific_tags-vascular-access"],"acf":{"sc_authors":""},"yoast_head":"\nEfficacy of Granulocyte Apheresis in Pediatric Patients With\u00a0Ulcerative Colitis: A Pilot Study - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/efficacy-of-granulocyte-apheresis-in-pediatric-patients-with-ulcerative-colitis-a-pilot-study\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficacy of Granulocyte Apheresis in Pediatric Patients With\u00a0Ulcerative Colitis: A Pilot Study - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Ikeda, Hitoshi; Ishimaru, Yuki; Takayasu, Hajime; Fujino, Junko; Kisaki, Yoshiyuki; Otani, Yushi; Yamagishi, Junko; Tahara, Kazunori. J Pediatr Gastroenterol Nutr 2006; 43:592-6. doi: 10.1097\/01.mpg.0000237928.07729.79 Objectives: Granulocyte apheresis (GCAP), involving the removal of granulocytes from the blood, may improve clinical symptoms and facilitate a reduction in the dose of steroids in adult patients with ulcerative colitis. 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