{"id":6608,"date":"2003-04-10T14:24:00","date_gmt":"2003-04-10T14:24:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6608"},"modified":"2022-04-01T11:48:53","modified_gmt":"2022-04-01T11:48:53","slug":"granulocyte-adsorptive-apheresis-for-pediatric-patients-with-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/granulocyte-adsorptive-apheresis-for-pediatric-patients-with-ulcerative-colitis\/","title":{"rendered":"Granulocyte adsorptive apheresis for pediatric patients with ulcerative colitis"},"content":{"rendered":"
\n

Takeshi Tomomasa<\/a> 1<\/a><\/sup>, Akio Kobayashi<\/a>, Hiroaki Kaneko<\/a>, Sasaki Mika<\/a>, Shun-Ichi Maisawa<\/a>, Yoshie Chino<\/a>, Hohkibara Syou<\/a>, Atsushi Yoden<\/a>, Jyunko Fujino<\/a>, Makoto Tanikawa<\/a>, Takafumi Yamashita<\/a>, Shigeru Kimura<\/a>, Maiko Kanoh<\/a>, Koji Sawada<\/a>, Akihiro Morikawa<\/a><\/p>\n<\/div>\n\n

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Dig Dis Sci.<\/a> 2003 Apr;48(4):750-4. doi: 10.1023\/a:1022892927121.<\/p>\n<\/div>\n\n

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Granulocytapheresis (GCAP) has produced efficacy in adult patients with ulcerative colitis (UC) by adsorbing activated granulocytes and monocytes\/macrophages. We retrospectively investigated efficacy and safety of GCAP in pediatric patients with active UC. Twelve steroid-refractory children (12.2 +\/- 3.1 years old) were treated with GCAP, one session\/week for 5-10 consecutive weeks. In 8 patients, clinical symptoms improved after two GCAP sessions. Normal body temperature, stool frequency, and disappearance of blood in stool were seen after 24.3 +\/- 11.5 days. The endoscopic grade improved from 2.6 +\/- 0.3 to 0.4 +\/- 0.2. One patient who initially responded, developed bloody diarrhea later and 2 cases remained unchanged. The dose of steroid was tapered during GCAP therapy by 50%. No serious adverse effects were noted. Four of 8 cases relapsed 3.5 +\/- 2.2 months after the last GCAP while on maintenance therapy, the other 4 were in remission up to 22.8 +\/- 18.1 months. In conclusion, GCAP appears to be effective and well tolerated in children with steroid-refractory UC.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/12741466\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Takeshi Tomomasa 1, Akio Kobayashi, Hiroaki Kaneko, Sasaki Mika, Shun-Ichi Maisawa, Yoshie Chino, Hohkibara Syou, Atsushi Yoden, Jyunko Fujino, Makoto Tanikawa, Takafumi Yamashita, Shigeru Kimura, Maiko Kanoh, Koji Sawada, Akihiro Morikawa Dig Dis Sci. 2003 Apr;48(4):750-4. doi: 10.1023\/a:1022892927121. Granulocytapheresis (GCAP) has produced efficacy in adult patients with ulcerative colitis (UC) by adsorbing activated granulocytes and monocytes\/macrophages. We retrospectively investigated efficacy and safety of GCAP in pediatric patients with active UC. Twelve steroid-refractory […]<\/p>\n","protected":false},"template":"","scientific_tags":[502,147,602,397,424,597,405,313,156,55,135,604,306],"class_list":["post-6608","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-children","scientific_tags-clinical-remission","scientific_tags-cyclosporine-a","scientific_tags-endoscopic-remission","scientific_tags-gma","scientific_tags-paediatric","scientific_tags-pediatric","scientific_tags-pediatry","scientific_tags-safety","scientific_tags-steroid-dependent","scientific_tags-steroid-refractory","scientific_tags-steroid-tapering-2","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"\nGranulocyte adsorptive apheresis for pediatric patients with ulcerative colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocyte-adsorptive-apheresis-for-pediatric-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocyte adsorptive apheresis for pediatric patients with ulcerative colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Takeshi Tomomasa 1, Akio Kobayashi, Hiroaki Kaneko, Sasaki Mika, Shun-Ichi Maisawa, Yoshie Chino, Hohkibara Syou, Atsushi Yoden, Jyunko Fujino, Makoto Tanikawa, Takafumi Yamashita, Shigeru Kimura, Maiko Kanoh, Koji Sawada, Akihiro Morikawa Dig Dis Sci. 2003 Apr;48(4):750-4. doi: 10.1023\/a:1022892927121. 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