{"id":6510,"date":"2011-12-14T14:35:00","date_gmt":"2011-12-14T14:35:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=6510"},"modified":"2021-12-14T14:37:41","modified_gmt":"2021-12-14T14:37:41","slug":"relevance-of-the-processed-blood-volume-per-granulocyte-and-monocyte-apheresis-session-to-its-clinical-efficacy-in-patients-with-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/relevance-of-the-processed-blood-volume-per-granulocyte-and-monocyte-apheresis-session-to-its-clinical-efficacy-in-patients-with-ulcerative-colitis\/","title":{"rendered":"Relevance of the Processed Blood Volume per Granulocyte and Monocyte Apheresis Session to its Clinical Efficacy in Patients With Ulcerative Colitis"},"content":{"rendered":"
\n

Risa Kikuyama<\/a>,Ken Fukunaga<\/a>,Mikio Kawai<\/a>,Yoko Yokoyama<\/a>,Koji Kamikozuru<\/a>,Nobuyuki Hida<\/a>,Yoshio Ohda<\/a>,Naohisa Takeda<\/a>,Koji Yoshida<\/a>,Masaki Iimuro<\/a>,Kyoichi Kato<\/a>,Tomoaki Kono<\/a>,Koji Nogami<\/a>,Kazuko Nagase<\/a>,Shiro Nakamura<\/a>,Yoshiyuki Takei<\/a>,Hiroto Miwa<\/a>,Takayuki Matsumoto<\/a>, https:\/\/doi.org\/10.1111\/j.1744-9987.2011.00968.x<\/p>\n<\/div>\n\n

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Granulocyte\/monocyte adsorption (GMA) has been introduced as an adjunct intervention for active ulcerative colitis (UC) patients. The processed blood volume (PV) per GMA session is an important factor for its efficacy because depletion of elevated\/activated myeloid leukocytes is its main action. Hitherto, this aspect of GMA has been largely ignored. Thirty-three patients were enrolled for remission induction therapy with five weekly GMA sessions at a standard PV of 1800\u2003mL, regardless of patients’ bodyweight (BW). The patients were divided into three groups: high (H)BW (\u226565\u2003kg,\u00a0n<\/em>\u2003=\u200311), 50\u2003kg\u2003\u2264\u2003medium (M)BW\u2003<\u200365\u2003kg (n<\/em>\u2003=\u200312), and low (L)BW (\u226450\u2003kg,\u00a0n<\/em>\u2003=\u200310). UC clinical activity index (CAI) was according to Lichtiger, and the clinical efficacies were evaluated at both one week post 3rd<\/sup>\u00a0GMA (Week 4) and one week post 5th<\/sup>\u00a0GMA (Week 6). The average BW was 70.9\u2003\u00b1\u20036.2\u2003kg in HBW, 55.8\u2003\u00b1\u20034.5\u2003kg in MBW, and 46.8\u2003\u00b1\u20031.2\u2003kg in LBW, indicating the mean PV\/BW in the three groups being 25.6\u2003\u00b1\u20032.12, 32.5\u2003\u00b1\u20032.50, and 38.7\u2003\u00b1\u20031.0 (mL\/kg,\u00a0P<\/em>\u2003<\u20030.05), respectively. The LBW group consisted of female patients only. Significant improvements of CAI were seen before treatment at either Week 4 or Week 6 in all groups. A significantly higher remission rate was achieved in the LBW (80.0%) vs. MBW (33.3%) or HBW (27.3%) at Week 6 (P<\/em>\u2003<\u20030.03). According to this GMA evaluation, the lower-limit of optimum PV\/kg should be higher than 38.7\u2003mL\/kg for its potential clinical efficacy to be significantly greater than the routine GMA method. Additional BW-oriented GMA studies in larger and gender controlled cohorts of patients should strengthen our findings.\u2003<\/p>\n<\/div>\n\n

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https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2011.00968.x<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Risa Kikuyama,Ken Fukunaga,Mikio Kawai,Yoko Yokoyama,Koji Kamikozuru,Nobuyuki Hida,Yoshio Ohda,Naohisa Takeda,Koji Yoshida,Masaki Iimuro,Kyoichi Kato,Tomoaki Kono,Koji Nogami,Kazuko Nagase,Shiro Nakamura,Yoshiyuki Takei,Hiroto Miwa,Takayuki Matsumoto, https:\/\/doi.org\/10.1111\/j.1744-9987.2011.00968.x Granulocyte\/monocyte adsorption (GMA) has been introduced as an adjunct intervention for active ulcerative colitis (UC) patients. The processed blood volume (PV) per GMA session is an important factor for its efficacy because depletion of elevated\/activated […]<\/p>\n","protected":false},"template":"","scientific_tags":[424,306],"class_list":["post-6510","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-gma","scientific_tags-ulcerative-colitis"],"acf":{"sc_authors":""},"yoast_head":"\nRelevance of the Processed Blood Volume per Granulocyte and Monocyte Apheresis Session to its Clinical Efficacy in Patients With Ulcerative Colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/relevance-of-the-processed-blood-volume-per-granulocyte-and-monocyte-apheresis-session-to-its-clinical-efficacy-in-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Relevance of the Processed Blood Volume per Granulocyte and Monocyte Apheresis Session to its Clinical Efficacy in Patients With Ulcerative Colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Risa Kikuyama,Ken Fukunaga,Mikio Kawai,Yoko Yokoyama,Koji Kamikozuru,Nobuyuki Hida,Yoshio Ohda,Naohisa Takeda,Koji Yoshida,Masaki Iimuro,Kyoichi Kato,Tomoaki Kono,Koji Nogami,Kazuko Nagase,Shiro Nakamura,Yoshiyuki Takei,Hiroto Miwa,Takayuki Matsumoto, https:\/\/doi.org\/10.1111\/j.1744-9987.2011.00968.x Granulocyte\/monocyte adsorption (GMA) has been introduced as an adjunct intervention for active ulcerative colitis (UC) patients. 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