{"id":5708,"date":"1997-07-06T11:03:00","date_gmt":"1997-07-06T11:03:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=5708"},"modified":"2021-07-09T11:00:19","modified_gmt":"2021-07-09T11:00:19","slug":"granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/","title":{"rendered":"Granulocytapheresis in the treatment of patients with rheumatoid arthritis"},"content":{"rendered":"
\n

M Ohara<\/a> 1<\/a><\/sup>, A R Saniabadi<\/a>, S Kokuma<\/a>, I Hirata<\/a>, M Adachi<\/a>, T Agishi<\/a>, R Kasukawa<\/a>, Artif Organs. 1997 Sep;21(9):989-94.<\/p>\n<\/div>\n\n

\n

The G-1 column is an extracorporeal type granulocytapheresis device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. A total of 59 rheumatoid arthritis patients with elevated granulocyte counts from 4 hospitals in Japan received 2 apheresis sessions of 1 h duration\/week for a total of 8 times over a period of 4 weeks. About 55% of the leukocytes which entered the G-1 column were adsorbed onto the beads: 95% were granulocytes, 3.5% monocytes, and 0.4% lymphocytes. Clinical and efficacy assessments showed improvements in swollen joints (p < 0.01), tender joints (p < 0.001), the active joint score (p < 0.001), duration of morning stiffness (p < 0.01), and grip strength (p < 0.001). In good responders, the improvements were observed for up to 12 weeks following the last apheresis. Exacerbation was noted in 2 patients. It is suggested that the efficacy of the G-1 column is attributable to the removal or suppression of hyperactive leukocytes and inflammatory cytokines, inducing a kind of immunomodulation.<\/p>\n<\/div>\n\n

\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/9288869\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

M Ohara 1, A R Saniabadi, S Kokuma, I Hirata, M Adachi, T Agishi, R Kasukawa, Artif Organs. 1997 Sep;21(9):989-94. The G-1 column is an extracorporeal type granulocytapheresis device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. A total of 59 rheumatoid arthritis patients with elevated granulocyte counts from 4 hospitals in Japan received 2 apheresis […]<\/p>\n","protected":false},"template":"","scientific_tags":[336],"class_list":["post-5708","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-rheumatology"],"acf":[],"yoast_head":"\nGranulocytapheresis in the treatment of patients with rheumatoid arthritis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Granulocytapheresis in the treatment of patients with rheumatoid arthritis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"M Ohara 1, A R Saniabadi, S Kokuma, I Hirata, M Adachi, T Agishi, R Kasukawa, Artif Organs. 1997 Sep;21(9):989-94. The G-1 column is an extracorporeal type granulocytapheresis device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. A total of 59 rheumatoid arthritis patients with elevated granulocyte counts from 4 hospitals in Japan received 2 apheresis […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-09T11:00:19+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/\",\"name\":\"Granulocytapheresis in the treatment of patients with rheumatoid arthritis - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"1997-07-06T11:03:00+00:00\",\"dateModified\":\"2021-07-09T11:00:19+00:00\",\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Granulocytapheresis in the treatment of patients with rheumatoid arthritis - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/","og_locale":"fr_FR","og_type":"article","og_title":"Granulocytapheresis in the treatment of patients with rheumatoid arthritis - Adacyte","og_description":"M Ohara 1, A R Saniabadi, S Kokuma, I Hirata, M Adachi, T Agishi, R Kasukawa, Artif Organs. 1997 Sep;21(9):989-94. The G-1 column is an extracorporeal type granulocytapheresis device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. A total of 59 rheumatoid arthritis patients with elevated granulocyte counts from 4 hospitals in Japan received 2 apheresis […]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/","og_site_name":"Adacyte","article_modified_time":"2021-07-09T11:00:19+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/","name":"Granulocytapheresis in the treatment of patients with rheumatoid arthritis - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"1997-07-06T11:03:00+00:00","dateModified":"2021-07-09T11:00:19+00:00","inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/granulocytapheresis-in-the-treatment-of-patients-with-rheumatoid-arthritis\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/scientific-corner\/5708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/media?parent=5708"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/scientific_tags?post=5708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}