{"id":5621,"date":"2009-07-05T14:24:00","date_gmt":"2009-07-05T14:24:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=5621"},"modified":"2021-07-09T11:18:50","modified_gmt":"2021-07-09T11:18:50","slug":"biological-effect-of-anaphylatoxin-c5a-on-the-generation-of-anti-inflammatory-substances-in-leukocyte-adsorption","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/biological-effect-of-anaphylatoxin-c5a-on-the-generation-of-anti-inflammatory-substances-in-leukocyte-adsorption\/","title":{"rendered":"Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nishise+S&amp;cauthor_id=19954474\">Shoichi Nishise<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19954474\/#affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Takeda+Y&amp;cauthor_id=19954474\">Yuji Takeda<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nishise+Y&amp;cauthor_id=19954474\">Yuko Nishise<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fujishima+S&amp;cauthor_id=19954474\">Shoichiro Fujishima<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Orii+T&amp;cauthor_id=19954474\">Tomohiko Orii<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Otake+S&amp;cauthor_id=19954474\">Sayaka Otake<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sato+T&amp;cauthor_id=19954474\">Takeshi Sato<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sasaki+Y&amp;cauthor_id=19954474\">Yu Sasaki<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Takeda+H&amp;cauthor_id=19954474\">Hiroaki Takeda<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kawata+S&amp;cauthor_id=19954474\">Sumio Kawata<\/a>, Ther Apher Dial. 2009 Dec;13(6):509-14.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed the anti-inflammatory effects of C5a, the strongest anaphylatoxin, in granulocyte and monocyte adsorptive apheresis. The aim of this study was to investigate the effect of C5a on interleukin-1 receptor antagonist (IL-1ra) and hepatocyte growth factor (HGF) generation in granulocyte and monocyte adsorption. Peripheral blood containing nafamostat mesilate as an endogenous complement activation inhibitor was divided into four groups: (1) no recombinant C5a added, no contact with cellulose acetate (CA) beads (control group); (2) no C5a added, contact with CA beads; (3) C5a added, no contact with CA beads; and (4) C5a added, contact with CA beads. After incubation, IL-1ra and HGF in plasma were measured. IL-1ra was significantly higher in group 3, in which only C5a was added in the absence of CA beads, compared to groups 2 (P &lt; 0.01) and 4 (P &lt; 0.05). HGF was significantly higher only in group 4, in which C5a was added in the presence of CA beads (P &lt; 0.05), but did not increase in the absence of CA beads. C5a can directly induce IL-1ra generation without the granulocyte and monocyte adsorption stimuli to CA beads, but can synergistically induce HGF generation with the adsorption stimuli, indicating C5a has different effects on IL-1ra and HGF generation.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19954474\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/19954474\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Shoichi Nishise&nbsp;1,&nbsp;Yuji Takeda,&nbsp;Yuko Nishise,&nbsp;Shoichiro Fujishima,&nbsp;Tomohiko Orii,&nbsp;Sayaka Otake,&nbsp;Takeshi Sato,&nbsp;Yu Sasaki,&nbsp;Hiroaki Takeda,&nbsp;Sumio Kawata, Ther Apher Dial. 2009 Dec;13(6):509-14. Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed the anti-inflammatory effects of C5a, the strongest anaphylatoxin, in granulocyte and monocyte adsorptive apheresis. The [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[],"class_list":["post-5621","scientific-corner","type-scientific-corner","status-publish","hentry"],"acf":{"sc_authors":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/biological-effect-of-anaphylatoxin-c5a-on-the-generation-of-anti-inflammatory-substances-in-leukocyte-adsorption\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Shoichi Nishise&nbsp;1,&nbsp;Yuji Takeda,&nbsp;Yuko Nishise,&nbsp;Shoichiro Fujishima,&nbsp;Tomohiko Orii,&nbsp;Sayaka Otake,&nbsp;Takeshi Sato,&nbsp;Yu Sasaki,&nbsp;Hiroaki Takeda,&nbsp;Sumio Kawata, Ther Apher Dial. 2009 Dec;13(6):509-14. Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed the anti-inflammatory effects of C5a, the strongest anaphylatoxin, in granulocyte and monocyte adsorptive apheresis. 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Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed the anti-inflammatory effects of C5a, the strongest anaphylatoxin, in granulocyte and monocyte adsorptive apheresis. 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