{"id":5589,"date":"2012-07-01T09:18:00","date_gmt":"2012-07-01T09:18:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&#038;p=5589"},"modified":"2022-01-28T14:35:19","modified_gmt":"2022-01-28T14:35:19","slug":"leukocytapheresis-for-steroid-dependent-ulcerative-colitis-in-clinical-practice-results-of-a-nationwide-spanish-registry","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/leukocytapheresis-for-steroid-dependent-ulcerative-colitis-in-clinical-practice-results-of-a-nationwide-spanish-registry\/","title":{"rendered":"Leukocytapheresis for steroid-dependent ulcerative colitis in clinical practice: results of a nationwide Spanish registry"},"content":{"rendered":"<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cabriada+JL&amp;cauthor_id=22105230\">J L Cabriada<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22105230\/#affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Dom%C3%A8nech+E&amp;cauthor_id=22105230\">E Dom\u00e8nech<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ibargoyen+N&amp;cauthor_id=22105230\">N Ibargoyen<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hern%C3%A1ndez+V&amp;cauthor_id=22105230\">V Hern\u00e1ndez<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Clofent+J&amp;cauthor_id=22105230\">J Clofent<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ginard+D&amp;cauthor_id=22105230\">D Ginard<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Guti%C3%A9rrez-Ibarluzea+I&amp;cauthor_id=22105230\">I Guti\u00e9rrez-Ibarluzea<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hinojosa+J&amp;cauthor_id=22105230\">J Hinojosa<\/a>, J Gastroenterol. 2012 Apr;47(4):359-65.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p>&nbsp;<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><strong>Background:&nbsp;<\/strong>Several small, prospective, open studies suggest that leukocytapheresis might be efficient in patients with steroid-dependent ulcerative colitis (UC). <strong>Aim:&nbsp;<\/strong>To evaluate the short- and long-term effectiveness of leukocytapheresis for the management of steroid-dependent UC in clinical practice. <strong>Methods:&nbsp;<\/strong>A Web-based, nationwide database specifically designed to record the efficacy and safety data of leukocytapheresis therapy in UC was available from September 2007 in Spain. Clinical data were collected at treatment baseline, 1 month after the last apheresis session (initial efficacy), and 6 and 12 months thereafter (long-term efficacy). Remission was defined as a Mayo Clinic index \u22642 together with complete steroid withdrawal and response as a decrease of \u22653 from the baseline score. <strong>Results:&nbsp;<\/strong>A total of 142 steroid-dependent UC patients were included in the registry, most of them treated with the Adacolumn\u2122 system. In 69% of patients thiopurine therapy failed to achieve steroid-free clinical remission. Initial clinical remission was obtained in 37% of cases. The initial corticosteroid dose, the number and frequency of apheresis sessions, or the previous failure of thiopurines and\/or infliximab did not influence the initial remission rate, but a greater decrease in CRP levels was associated with a higher probability to obtain initial remission. At 6 and 12 months, 41 and 36% of patients were in clinical remission, respectively. Only one serious adverse effect was recorded. Conclusions: In clinical practice, apheresis allows long-term steroid-free clinical remission in up to one third of steroid-dependent UC patients, even in those with prior failure of thiopurines.<\/p>\n<\/div>\n\n<div class=\"post-content max-w-987 mx-auto px-20 lg:px-0\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22105230\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22105230\/<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J L Cabriada&nbsp;1,&nbsp;E Dom\u00e8nech,&nbsp;N Ibargoyen,&nbsp;V Hern\u00e1ndez,&nbsp;J Clofent,&nbsp;D Ginard,&nbsp;I Guti\u00e9rrez-Ibarluzea,&nbsp;J Hinojosa, J Gastroenterol. 2012 Apr;47(4):359-65. &nbsp; Background:&nbsp;Several small, prospective, open studies suggest that leukocytapheresis might be efficient in patients with steroid-dependent ulcerative colitis (UC). Aim:&nbsp;To evaluate the short- and long-term effectiveness of leukocytapheresis for the management of steroid-dependent UC in clinical practice. Methods:&nbsp;A Web-based, nationwide database [&hellip;]<\/p>\n","protected":false},"template":"","scientific_tags":[147,424,74,81,225,522,55,334,306],"class_list":["post-5589","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-clinical-remission","scientific_tags-gma","scientific_tags-leukocytapheresis","scientific_tags-long-term-outcome","scientific_tags-registry","scientific_tags-short-term-outcome","scientific_tags-steroid-dependent","scientific_tags-steroid-free-remission","scientific_tags-ulcerative-colitis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Leukocytapheresis for steroid-dependent ulcerative colitis in clinical practice: results of a nationwide Spanish registry - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/leukocytapheresis-for-steroid-dependent-ulcerative-colitis-in-clinical-practice-results-of-a-nationwide-spanish-registry\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Leukocytapheresis for steroid-dependent ulcerative colitis in clinical practice: results of a nationwide Spanish registry - Adacyte\" \/>\n<meta property=\"og:description\" content=\"J L Cabriada&nbsp;1,&nbsp;E Dom\u00e8nech,&nbsp;N Ibargoyen,&nbsp;V Hern\u00e1ndez,&nbsp;J Clofent,&nbsp;D Ginard,&nbsp;I Guti\u00e9rrez-Ibarluzea,&nbsp;J Hinojosa, J Gastroenterol. 2012 Apr;47(4):359-65. &nbsp; Background:&nbsp;Several small, prospective, open studies suggest that leukocytapheresis might be efficient in patients with steroid-dependent ulcerative colitis (UC). Aim:&nbsp;To evaluate the short- and long-term effectiveness of leukocytapheresis for the management of steroid-dependent UC in clinical practice. 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