{"id":3925,"date":"2019-04-17T07:08:00","date_gmt":"2019-04-17T07:08:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=3925"},"modified":"2024-05-02T11:12:26","modified_gmt":"2024-05-02T09:12:26","slug":"efficacy-and-safety-of-adsorptive-granulocyte-and-monocyte-apheresis-in-elderly-and-pregnant-patients-with-ulcerative-colitis","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/efficacy-and-safety-of-adsorptive-granulocyte-and-monocyte-apheresis-in-elderly-and-pregnant-patients-with-ulcerative-colitis\/","title":{"rendered":"Efficacy and Safety of Adsorptive Granulocyte and Monocyte Apheresis in Elderly and Pregnant Patients With Ulcerative Colitis"},"content":{"rendered":"
\n

Kazuki Yanagisawa<\/a>\u00a01<\/a><\/sup>,\u00a0Minoru Murakami<\/a>\u00a02<\/a><\/sup>,\u00a0Yuya Kondo<\/a>\u00a01<\/a><\/sup>,\u00a0Shun Oguma<\/a>\u00a01<\/a><\/sup>,\u00a0Shun Kobayashi<\/a>\u00a01<\/a><\/sup>,\u00a0Hiroshi Miyasaka<\/a>\u00a01<\/a><\/sup>,\u00a0Tomoaki Shinohara<\/a>\u00a03<\/a><\/sup>,\u00a0Akihisa Tomori<\/a>\u00a03<\/a><\/sup>,\u00a0Yui Nakano<\/a>\u00a02<\/a><\/sup>,\u00a0Shunichi Furuhata<\/a>\u00a02<\/a><\/sup>,\u00a0Masaya Ikezoe<\/a>\u00a02<\/a><\/sup> , Ther Apher Dial 2019 Jun;23(3):217-223.<\/p>\n<\/div>\n\n

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In patients with active ulcerative colitis (UC), adsorptive granulocyte\/monocyte apheresis (GMA) is expected to promote remission. We conducted a retrospective cohort study to evaluate the efficacy and safety of GMA in patients with active UC. Twenty\u2010one UC patients including five pregnant or lactating mothers and four elderly patients (aged >60\u2009years) received up to 10 GMA sessions. UC severity was evaluated at baseline and after GMA therapy according to Lichtiger’s Clinical Activity Index (CAI). We defined clinical remission as CAI \u22644. Overall, the median CAI score after GMA therapy had decreased from 9 to 4 (P<\/em>\u2009<\u20090.001). The clinical remission rate was 62%, but in the elderly and pregnant or lactating mothers, the remission rates were 100% and 60%, respectively. No severe adverse effects were seen in this study. Our results may support GMA as an effective and safe treatment for active UC patients, including elderly patients and pregnant cases.<\/p>\n<\/div>\n\n

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https:\/\/pubmed.ncbi.nlm.nih.gov\/31025815\/<\/a><\/p>\n<\/div>\n\n

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https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6852531\/pdf\/TAP-23-217.pdf<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Kazuki Yanagisawa\u00a01,\u00a0Minoru Murakami\u00a02,\u00a0Yuya Kondo\u00a01,\u00a0Shun Oguma\u00a01,\u00a0Shun Kobayashi\u00a01,\u00a0Hiroshi Miyasaka\u00a01,\u00a0Tomoaki Shinohara\u00a03,\u00a0Akihisa Tomori\u00a03,\u00a0Yui Nakano\u00a02,\u00a0Shunichi Furuhata\u00a02,\u00a0Masaya Ikezoe\u00a02 , Ther Apher Dial 2019 Jun;23(3):217-223. In patients with active ulcerative colitis (UC), adsorptive granulocyte\/monocyte apheresis (GMA) is expected to promote remission. We conducted a retrospective cohort study to evaluate the efficacy and safety of GMA in patients with active UC. Twenty\u2010one UC […]<\/p>\n","protected":false},"template":"","scientific_tags":[71,72,311],"class_list":["post-3925","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-lactation","scientific_tags-pregnancy","scientific_tags-special-situations"],"acf":{"sc_authors":"https:\/\/pubmed.ncbi.nlm.nih.gov\/31025815\/<\/a>\r\n\r\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6852531\/pdf\/TAP-23-217.pdf<\/a>"},"yoast_head":"\nEfficacy and Safety of Adsorptive Granulocyte and Monocyte Apheresis in Elderly and Pregnant Patients With Ulcerative Colitis - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/efficacy-and-safety-of-adsorptive-granulocyte-and-monocyte-apheresis-in-elderly-and-pregnant-patients-with-ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficacy and Safety of Adsorptive Granulocyte and Monocyte Apheresis in Elderly and Pregnant Patients With Ulcerative Colitis - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Kazuki Yanagisawa\u00a01,\u00a0Minoru Murakami\u00a02,\u00a0Yuya Kondo\u00a01,\u00a0Shun Oguma\u00a01,\u00a0Shun Kobayashi\u00a01,\u00a0Hiroshi Miyasaka\u00a01,\u00a0Tomoaki Shinohara\u00a03,\u00a0Akihisa Tomori\u00a03,\u00a0Yui Nakano\u00a02,\u00a0Shunichi Furuhata\u00a02,\u00a0Masaya Ikezoe\u00a02 , Ther Apher Dial 2019 Jun;23(3):217-223. In patients with active ulcerative colitis (UC), adsorptive granulocyte\/monocyte apheresis (GMA) is expected to promote remission. We conducted a retrospective cohort study to evaluate the efficacy and safety of GMA in patients with active UC. 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