{"id":11006,"date":"2024-01-07T12:25:00","date_gmt":"2024-01-07T11:25:00","guid":{"rendered":"https:\/\/www.adacyte.com\/?post_type=scientific-corner&p=11006"},"modified":"2025-08-07T12:29:34","modified_gmt":"2025-08-07T10:29:34","slug":"phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer","status":"publish","type":"scientific-corner","link":"https:\/\/www.adacyte.com\/fr\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/","title":{"rendered":"Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer"},"content":{"rendered":"
\n

Ronen Sumagin<\/a>\u00a01<\/a><\/sup><\/p>\n<\/div>\n\n

\n

Am J Pathol .\u00a02024 Jan;194(1):2-12.\u00a0doi: 10.1016\/j.ajpath.2023.10.009.\u00a0Epub 2023 Nov 2.<\/p>\n<\/div>\n\n

\n

Neutrophils [polymorphonuclear leukocytes (PMNs)] execute important effector functions protecting the host against invading pathogens. However, their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently, PMNs were considered to be short-lived, terminally differentiated phagocytes. However, this view is rapidly changing with the emerging evidence of increased PMN lifespan in tissues, PMN plasticity, and phenotypic heterogeneity. Specialized PMN subsets have been identified in inflammation and in developing tumors, consistent with both beneficial and detrimental functions of PMNs in these conditions. Because PMN and tumor-associated neutrophil activity and the resulting beneficial\/detrimental impacts primarily occur after homing to inflamed tissue\/tumors, studying the underlying mechanisms of PMN\/tumor-associated neutrophil trafficking is of high interest and clinical relevance. This review summarizes some of the key findings from over a decade of work from my laboratory and others on the regulation of PMN recruitment and identification of phenotypically and functionally diverse PMN subtypes as they pertain to gut inflammation and colon cancer.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Ronen Sumagin\u00a01 Am J Pathol .\u00a02024 Jan;194(1):2-12.\u00a0doi: 10.1016\/j.ajpath.2023.10.009.\u00a0Epub 2023 Nov 2. Neutrophils [polymorphonuclear leukocytes (PMNs)] execute important effector functions protecting the host against invading pathogens. However, their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently, PMNs were considered to be short-lived, terminally differentiated phagocytes. However, this view is rapidly […]<\/p>\n","protected":false},"template":"","scientific_tags":[324,821,832,327,312,106,445,366,318,830,831],"class_list":["post-11006","scientific-corner","type-scientific-corner","status-publish","hentry","scientific_tags-cancer","scientific_tags-clusters","scientific_tags-colon-cancer","scientific_tags-gut-microbiota","scientific_tags-immunology","scientific_tags-inflammation","scientific_tags-neutrophil","scientific_tags-neutrophil-infiltration","scientific_tags-oncology","scientific_tags-phenotypes","scientific_tags-pmn"],"acf":[],"yoast_head":"\nPhenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer - Adacyte<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer - Adacyte\" \/>\n<meta property=\"og:description\" content=\"Ronen Sumagin\u00a01 Am J Pathol .\u00a02024 Jan;194(1):2-12.\u00a0doi: 10.1016\/j.ajpath.2023.10.009.\u00a0Epub 2023 Nov 2. Neutrophils [polymorphonuclear leukocytes (PMNs)] execute important effector functions protecting the host against invading pathogens. However, their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently, PMNs were considered to be short-lived, terminally differentiated phagocytes. However, this view is rapidly […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Adacyte\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-07T10:29:34+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/\",\"url\":\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/\",\"name\":\"Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer - Adacyte\",\"isPartOf\":{\"@id\":\"https:\/\/www.adacyte.com\/#website\"},\"datePublished\":\"2024-01-07T11:25:00+00:00\",\"dateModified\":\"2025-08-07T10:29:34+00:00\",\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.adacyte.com\/#website\",\"url\":\"https:\/\/www.adacyte.com\/\",\"name\":\"Adacyte\",\"description\":\"Adacyte Therapeutics\",\"publisher\":{\"@id\":\"https:\/\/www.adacyte.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.adacyte.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.adacyte.com\/#organization\",\"name\":\"Adacyte\",\"url\":\"https:\/\/www.adacyte.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"contentUrl\":\"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg\",\"width\":165,\"height\":46,\"caption\":\"Adacyte\"},\"image\":{\"@id\":\"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer - Adacyte","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/","og_locale":"fr_FR","og_type":"article","og_title":"Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer - Adacyte","og_description":"Ronen Sumagin\u00a01 Am J Pathol .\u00a02024 Jan;194(1):2-12.\u00a0doi: 10.1016\/j.ajpath.2023.10.009.\u00a0Epub 2023 Nov 2. Neutrophils [polymorphonuclear leukocytes (PMNs)] execute important effector functions protecting the host against invading pathogens. However, their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently, PMNs were considered to be short-lived, terminally differentiated phagocytes. However, this view is rapidly […]","og_url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/","og_site_name":"Adacyte","article_modified_time":"2025-08-07T10:29:34+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/","url":"https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/","name":"Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer - Adacyte","isPartOf":{"@id":"https:\/\/www.adacyte.com\/#website"},"datePublished":"2024-01-07T11:25:00+00:00","dateModified":"2025-08-07T10:29:34+00:00","inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.adacyte.com\/professional\/scientific-corner\/phenotypic-and-functional-diversity-of-neutrophils-in-gut-inflammation-and-cancer\/"]}]},{"@type":"WebSite","@id":"https:\/\/www.adacyte.com\/#website","url":"https:\/\/www.adacyte.com\/","name":"Adacyte","description":"Adacyte Therapeutics","publisher":{"@id":"https:\/\/www.adacyte.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.adacyte.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.adacyte.com\/#organization","name":"Adacyte","url":"https:\/\/www.adacyte.com\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","contentUrl":"https:\/\/www.adacyte.com\/wp-content\/uploads\/2021\/01\/logo-adacyte.svg","width":165,"height":46,"caption":"Adacyte"},"image":{"@id":"https:\/\/www.adacyte.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/scientific-corner\/11006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/scientific-corner"}],"about":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/types\/scientific-corner"}],"wp:attachment":[{"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/media?parent=11006"}],"wp:term":[{"taxonomy":"scientific_tags","embeddable":true,"href":"https:\/\/www.adacyte.com\/fr\/wp-json\/wp\/v2\/scientific_tags?post=11006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}